14gs Summary

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GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 1

The structure was published by Oakley, A.J., Lo Bello, M., Ricci, G., Federici, G., and Parker, M.W., in 1998 in a paper entitled "Evidence for an induced-fit mechanism operating in pi class glutathione transferases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLUTATHIONE S-TRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTATHIONE S-TRANSFERASE P09211 (1-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 210 92%
B GLUTATHIONE S-TRANSFERASE P09211 (1-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 210 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09211 (1 - 210) GLUTATHIONE S-TRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P09211) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P09211) glutathione transferase activitysearch S-nitrosoglutathione bindingsearch protein bindingsearch kinase regulator activitysearch dinitrosyl-iron complex bindingsearch transferase activitysearch nitric oxide bindingsearch JUN kinase bindingsearch metabolic processsearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of interleukin-1 beta productionsearch negative regulation of tumor necrosis factor-mediated signaling pathwaysearch negative regulation of apoptotic processsearch negative regulation of ERK1 and ERK2 cascadesearch negative regulation of JUN kinase activitysearch negative regulation of monocyte chemotactic protein-1 productionsearch regulation of ERK1 and ERK2 cascadesearch glutathione derivative biosynthetic processsearch xenobiotic metabolic processsearch negative regulation of MAPK cascadesearch cellular response to lipopolysaccharidesearch negative regulation of protein kinase activitysearch regulation of stress-activated MAPK cascadesearch negative regulation of stress-activated MAPK cascadesearch nitric oxide storagesearch small molecule metabolic processsearch negative regulation of tumor necrosis factor productionsearch negative regulation of biosynthetic processsearch negative regulation of fibroblast proliferationsearch negative regulation of acute inflammatory responsesearch common myeloid progenitor cell proliferationsearch negative regulation of leukocyte proliferationsearch negative regulation of MAP kinase activitysearch glutathione metabolic processsearch central nervous system developmentsearch negative regulation of nitric-oxide synthase biosynthetic processsearch negative regulation of I-kappaB kinase/NF-kappaB signalingsearch response to reactive oxygen speciessearch positive regulation of superoxide anion generationsearch cytoplasmsearch extracellular vesicular exosomesearch extracellular spacesearch nucleussearch mitochondrionsearch intracellularsearch TRAF2-GSTP1 complexsearch cytosolsearch plasma membranesearch

Chain InterPro annotation
A, B Glutathione S-transferase, Pi classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch