12ca Summary

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ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121

The structure was published by Nair, S.K., Calderone, T.L., Christianson, D.W., and Fierke, C.A., in 1991 in a paper entitled "Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) kidney developmentsearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch response to pHsearch response to organic substancesearch response to zinc ionsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch response to estrogensearch regulation of anion transportsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch secretionsearch response to steroid hormonesearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch extracellular spacesearch cytoplasmsearch cytosolsearch plasma membranesearch microvillussearch membranesearch basolateral plasma membranesearch axonsearch myelin sheathsearch apical part of cellsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch