10mh Summary

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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET

The structure was published by Sheikhnejad, G., Brank, A., Christman, J.K., et al., Sufrin, J.R., O'gara, M., and Cheng, X., in 1999 in a paper entitled "Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), and PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI) P05102 (1-327) (MTH1_HAEPH)search Haemophilus parahaemolyticussearch 100% 327 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05102 (1 - 327) PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI) Haemophilus haemolyticus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P05102) C5 cytosine-specific DNA methylase, DCMsearch Vaccinia Virus protein VP39search, DNA Methylase, subunit A, domain 2search PF00145: C-5 cytosine-specific DNA methylasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P05102) DNA methylationsearch C-5 methylation of cytosinesearch DNA restriction-modification systemsearch methylationsearch methyltransferase activitysearch transferase activitysearch DNA bindingsearch DNA (cytosine-5-)-methyltransferase activitysearch

Chain InterPro annotation
A C-5 cytosine methyltransferasesearch DNA methylase, C-5 cytosine-specific, active sitesearch S-adenosyl-L-methionine-dependent methyltransferasesearch