triangle PDBeMotif: 4jt8  
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coner
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Enzyme   3.5.1.
Classification hydrolase/hydrolase inhibitor    | release date: Fri, Mar 22, 2013
Title crystal structure of human sirt3 with elt inhibitor 28 [4-(4 dimethylpropanoyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]p 6-carboxamide[
Authors H.DAI
Method X-RAY DIFFRACTION (resolution: 2.26Å)
PDBe Citation   
Small molecules:    search ZN ZN binding statistics ZN   search 1NR 1NR binding statistics 1NR
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
SNASDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFT
LAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMA
DRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWH
PRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITO
member of: GENE3D:searchG3DSA_3.30.1600.10/searchG3DSA_3.40.50.1220PANTHER:searchPTHR11085/searchPTHR11085_SF14PFAM:searchPF02146PROSITE PROFILES:searchPS50305, SUPERFAMILY:searchSSF52467UniProt:searchQ9NTG7
JMol viewer RasMol script viewer  1NR 402A  ..                          *         **       *              *                                               ****                *                                           * *                                                                                                   
JMol viewer RasMol script viewer  ZN 401A  ..                          |         ||       |              |                                               ||||                |       *  *                    *  *        | |                                                                                                   
sec str:  ......hhhhhhhhhhh.....eeeee.hhhhhhhh.........hhhhhhhhhh..hhhhhhhhhhhhhhhhhhhhhhhhhh......hhhhhhhhhhhhh..eeeeee....hhhhhh..hhh.eee..eeeeeeee.....eee...hhhhhhh............eeeee.......hhhhhhhhhhhhhh.eeeee.......hhhhhh........eeeee....hhhhhh....eeeee.hhhhhhhhhhhhhhhhhhhhhhhhhhhh.
sequence :  ..KGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGK
seq num:  ..120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390 
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..|   |  ||  || ||||       |   || ||| | |||| |    |  | |    |  |   |  | |   |  |  | |||  ^***     || ||||    | | ||||| ||| | ||    || |||    | |            | |   |  | |       |  |            |  |       |||||    |||||||  |                 |  |     |   |  |  | ||||          | |
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..*   |  ||  || ||||       |   || ||| | |||| |    |  | |    |  |   |  | |   |  |  | |||  | |      || ||||    | | ||||| ||| | ||    || |||    | |            | |   |  | |       |  |            |  |       |||||    |||||||  |                 |  |     |   |  |  | ||||          ^**
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..    ^***|  || ||||       |   || ||| | |||| |    |  | |    |  |   |  | |   |  |  | |||  | |      || ||||    | | ||||| ||| | ||    || |||    | |            | |   |  | |       |  |            |  |       ^***|    ^***|||  |                 |  |     |   |  ^*** ||||             
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..    |   |  || ||||       ^***** ||| | |||| ^*****  | |    |  |   |  | |   |  |  | |||  | |      || ||||    | | ||||| |^*****|    ^*****    | |            | |   |  | |       |  |            |  |       |||||    |||||||  |                 |  |     |   |     | ||||             
search RasMol script viewer Motif-ligand binding stats  asxmotif ..    |   |  || ||||           || ||| *****| |       | |    |  |   |  | |   |  |  | |||  | |      || ||||    | | ||||| ||| |  |     | ||     | |            | |   |  | |       |  |            |  |       |||||    |||||||  |                 |  |     *****     | ||||             
search RasMol script viewer Motif-ligand binding stats  asxturn ..    |   |  || ||||           || ||| ***| | |       | |    |  |   |  | |   |  |  | |||  ***      || ||||    | | ***|| ||| |  |     | ||     | |            | |   |  | |       |  |            |  |       |||||    |||||||  |                 |  |               | ||||             
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..    |   |  || ||||           || ||| |  | | |       | |    |  |   |  | |   |  |  | |||           || ||||    | | ||||| ||| |  |     | ||     | |            | |   ******       |  |            |  |       |||||    |||||||  |                 |  |               | ||||             
search RasMol script viewer Motif-ligand binding stats  betaturn ..    |   |  |****||           |****| **** | |       | |    |  |   |  | |   |  |  ****|           |****||    | | ||||****| ****     | ||     | |            | |      | |       ****            |  |       |||||    *****||  |                 |  |               ****||             
search RasMol script viewer Motif-ligand binding stats  nest ..    |   |  |  ****           |  *** |  | | |       ***    |  |   |  | |   |  |  | ***           |  ****    | | ****  *** |  |     | ||     ***            ***      ***       |  |            |  |       |****      |  ||  |                 |  |                 ****             
search RasMol script viewer Motif-ligand binding stats  niche ..    |   |  |   ***           |    | **** ***              ****   **** |   |  **** ***           |   ***    ***    |    | ****     ****                                       ****            ****       | ***      ********                 ****                                  
search RasMol script viewer Motif-ligand binding stats  schellmannloop ..    |   |  ******            ******                                   |   |                     ******            ******          | |                                                                   | |                                                                       
search RasMol script viewer Motif-ligand binding stats  stmotif ..    *****                                                             |   |                                                       | |                                                                   | |                                                                       
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                                                      *****                                                       | |                                                                   | |                                                                       
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                                                                                                  ***                                                                   ***                                                                       

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