triangle PDBeMotif: 4frc  
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coner
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Enzyme   4.2.1.1
Classification lyase/lyase inhibitor    | release date: Tue, Jun 26, 2012
Title carbonic anhydrase ii in complex with n'-sulfamoylpyrrolidin carboximidamide
Authors A.DI PIZIO, A.HEINE, G.KLEBE
Method X-RAY DIFFRACTION (resolution: 0.98Å)
PDBe Citation   
Small molecules:    search ZN ZN binding statistics ZN   search DMS DMS binding statistics DMS   search 0VY 0VY binding statistics 0VY   search MBO MBO binding statistics MBO
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLK
GGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVV
DVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : CARBONIC ANHYDRASE 2
member of: GENE3D:searchG3DSA_3.10.200.10PANTHER:searchPTHR18952/searchPTHR18952_SF31PFAM:searchPF00194PROSITE PATTERNS:searchPS00162, PROSITE PROFILES:searchPS51144, SMART:searchSM01057SUPERFAMILY:searchSSF51069UniProt:searchP00918
JMol viewer RasMol script viewer  DMS 304A  ..   *                                                                                                                                                                                                                                          * * *              
JMol viewer RasMol script viewer  0VY 303A  ..   |                                                                                    * * *                      *          *           *                                                      ***                                          | | |              
JMol viewer RasMol script viewer  ZN 302A  ..   |                                                                                    | * *                      *          |           |                                                      |||                                          | | |              
JMol viewer RasMol script viewer  MBO 301A  ..   |                                                                                    | | |                      |          |   ****    |                                                      |||    **                                    | | |              
sec str:  .............hhhhhhhhhhh......ee.....ee....eeeeee.....eeeeee....eeeee.......eeeee.....eeeeeeeeee..........ee......eeeeeeeee.hhhhhhhhh.....eeeeeeeeee...hhhhhhhhhhhhhhh....eee....hhhhhh.....eeeeee..........eeeeee...eeehhhhhhhhh.............................ee...
sequence :  ..HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
seq num:  ..4         14        24        34        44        54        64        74        84        94        104       114       124       135       145       155       165       175       185       195       205       215       225       235       245       255    
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..  | |           | || |   |  | |||^** | ^**     |  | ^**  |||||     | ||       | |  ^**        | |  ||||  |  |      | |  |   || | |  |              ^**  |     || ^**|  |   || || |  |  | |        |     | |    | |    |   |  |  || ||  |                      ^**
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..  | |           | || |   ^*** ||| |  | ||      |  |      |||||     | ||       | |             | |  ||||  |  |      | |  |   || | |  |                |  |     || || |  |   |^*** |  |  | |        |     | |    | |    |   |  |  || ||  |                         
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..  | |           | || |        ||| |  | ||      |  |      |||||     | ||       | |             ^*****^*****  |      | |  |   || | |  |                |  |     || || |  |   |  |  |  |  | |        |     | |    | |    |   |  |  || ||  |                         
search RasMol script viewer Motif-ligand binding stats  ALPHA_CA_1 ..  | |           | || |        ||| |  | ||      |  |      |||||     | ||       | |               |  | **************^**  |   || | |  |                |  |     || || |  |   |  |  |  |  | |        |     | |    | |    |   |  |  || ||  |                         
search RasMol script viewer Motif-ligand binding stats  asxmotif ..  | |           | || |        ||| |  | ||      |  |      |||||     | ||       | |               |  |  |  |  |           *****| | |  |                |  |     || || |  |   |  |  |  |  | |        |     | |    | |    |   |  |  || ||  |                         
search RasMol script viewer Motif-ligand binding stats  asxturn ..  | |           | || |        *** |  ***|      |  |      ****|     ***|       | |               |  |  |  |  |                *** |  |                |  |     || || |  |   |  |  |  |  | |        |     | |    | |    |   |  |  || ||  |                         
search RasMol script viewer Motif-ligand binding stats  betaturn ..  | |           ******         |  |  |  |      |  |       ||||     |  |       | |               |  |  |  ****                    |  |                ****     ***** ****   |  |  |  |  | |        |     | |    | |    |   |  |  || ||  |                         
search RasMol script viewer Motif-ligand binding stats  nest ..  | |                          |  |  |  |      |  |       ****     |  |       | |               |  |  |                          |  |                               |  |   |  |  |  |  | |        |     | |    | |    |   |  |  || ||  |                         
search RasMol script viewer Motif-ligand binding stats  niche ..  ***                          ****  ****      ****         |      ****       ***               ****  |                          ****                               ****   ****  ****  ***        |     ***    ***    |   |  ***********                         
search RasMol script viewer Motif-ligand binding stats  stmotif ..                                                            |                                         |                                                                                | |        |                   *****                                      
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                            |                                         |                                                                                ***        |                                                              
search RasMol script viewer Motif-ligand binding stats  Catalytic site ..                                                            *                                         *                                                                                           *                                                              

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