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Classification immune system    | release date: Wed, Jan 11, 2012
Title hla-dr1 with covalently linked clip106-120 in reversed orien
Authors A.SCHLUNDT, C.FREUND, J.STICHT, M.WIECZOREK, S.GUENTHER, U.HEINEMA, Y.ROSKE
Method X-RAY DIFFRACTION (resolution: 2.20Å)
PDBe Citation   
Small molecules:    search GOL GOL binding statistics GOL
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
GGGGSGGGGSGGGGSIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAV
DKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLF
RKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTEN
Chain B sequence:
MGDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYC
RHNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLV
MLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSK
Chain C sequence:
MKMRMATPLLMQALPM
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA
member of: GENE3D:searchG3DSA_2.60.40.10/searchG3DSA_3.10.320.10PANTHER:searchPTHR19944/searchPTHR19944_SF27PFAM:searchPF00993/searchPF07654PROSITE PATTERNS:searchPS00290, PROSITE PROFILES:searchPS50835, SMART:searchSM00407/searchSM00920SUPERFAMILY:searchSSF48726/searchSSF54452UniProt:searchP01903
JMol viewer RasMol script viewer  GOL 1181A  ..                                                                                                            *                            *                                        
sec str:  ...eeeeeeeeeeee...eeeeeeee..eeeeeee....eeee.hhhhhh.ee.hhhhhhhhhhhhhhhhhhhhhhh..........eeeeee.........eeeeeeeeee.....eeeeee..ee.....ee...ee.....eeeeeeeee.......eeeeee.......eeeee..
sequence :  ..EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEF
seq num:  ..3         13        23        33        43        53        63        73        83        93        103       113       123       133       143       153       163       173     
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..|          |  | |      |  |     |  | || | |  || ||     |    |      |   | || |               |  |  |       |  |     ^***       | ||   |   | |||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..|          |  | |      |  |     |  **^* | |  || ||     |    |      |   | || |               |  |  |       |  |                | ||   |   | |||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..|          |  | |      |  |     |  | |  | |  || ||     |    |      |   ^**| |               |  |  |       |  |                | ||   |   | |||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..*          |  | |      |  |     |  | |  | |  || ||     |    |      |   |  | |               ^***  |       |  |                | ||   |   | |||           ^*** | |   |  |          
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..           |  | |      |  |     |  | |  | |  || ||     ^*****      |   |  | |                  |  |       |  |                | ^*****   | |||                | |   |  |          
search RasMol script viewer Motif-ligand binding stats  IG_MHC ..           |  | |      |  |     |  | |  | |  || ||                 |   |  | |                  |  |       |  |                |  |       | |||                **^****  |          
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..           |  | |      |  |     |  | |  | |  *****                 |   |  | |                  |  |       |  |                |  |       | |||                      |  |          
search RasMol script viewer Motif-ligand binding stats  betabulgeloop ..           ******      |  |     ******  | |  || ||                 |   |  | |                  |  |       |  |                |  |       | |||                      |  |          
search RasMol script viewer Motif-ligand binding stats  betaturn ..              | |      ****        | |  | *******|                 |   |  | |                  |  |       |  |                |  |       ****|                      ****          
search RasMol script viewer Motif-ligand binding stats  nest ..              ***                  ***  | |   |  |                 |   |  ***                  |  |       |  |                |  |         ***                      |  |          
search RasMol script viewer Motif-ligand binding stats  niche ..                                        ***   ****                 |   |                       ****       ****                ****                                  ****          
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                                                   *****                                                                                                          

chain B : HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1-1 BCHAIN;
member of: GENE3D:searchG3DSA_2.60.40.10/searchG3DSA_3.10.320.10PANTHER:searchPTHR19944/searchPTHR19944_SF42PFAM:searchPF00969/searchPF07654PRODOM:searchPD000328PROSITE PATTERNS:searchPS00290, PROSITE PROFILES:searchPS50835, SMART:searchSM00407/searchSM00921SUPERFAMILY:searchSSF48726/searchSSF54452UniProt:searchP04229
JMol viewer RasMol script viewer  GOL 1191B  ..                                                                              *                        ..                                                                              
sec str:  ......eeeeeeeeeeee....eeeeeeeeee..eeeeeee.....eee.hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh.......eeeeee.....eeeeeeeee.....eeeeee..eee...eee...ee.....eeeeeeee........eeeeee.......eeeee..
sequence :  ..TRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPSK..NLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA
seq num:  ..3         13        23        33        43        53        63        73        83        93           ..113       123       133       143       153       163       173       183     
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..                ^***| |      || | | | |  ||||   |  |      | ||||                 | |  ||  |            ..      |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..                  ^** |      || | ^** |  ||||   |  |      | ^**|                 | |  ||  |            ..      |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..                      |      || |   | |  ||||   |  |      | ^***                 | |  ||  |            ..      |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..                      *******^| |   ********^   |  |      |  |                   | |  ||  |            ..      |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..                              | |     |  |||    |  |      |  |                   ^*****|  |            ..      |  | | |           |||^*****   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  IG_MHC ..                              | |     |  |||    |  |      |  |                     |   |  |            ..      |  | | |           ||| | | |   |||||           |  | **^****  |          
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..                              | |     *****|    |  |      |  |                     |   |  |            ..      |  | | |           ||| | | |   |||||           |  |       |  |          
search RasMol script viewer Motif-ligand binding stats  betaturn ..                              | |     **** |    ****      |  |                     |   |  |            ..      |  | | |           ||| | | |   |||||           |  |       |  |          
search RasMol script viewer Motif-ligand binding stats  nest ..                              | |        ***              |  |                     |   |  |            ..      |  | | |           ||| | | |   *****           |  |       |  |          
search RasMol script viewer Motif-ligand binding stats  niche ..                              ***                         ****                     |   ****            ..      **** ***           ***** | |                   ****       ****          
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                                                                   *****               ..                               | |                                            
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                                                                       ..                               ***                                            

chain C : HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHA
member of: PANTHER:searchPTHR14093/searchPTHR14093_SF5PFAM:searchPF09307PIRSF:searchPIRSF001992PRINTS:searchCD74ANTIGENUniProt:searchP04233
JMol viewer RasMol script viewer  GOL 1191B  ..               
sec str:  ............ee...
sequence :  ..KMRMATPLLMQALPM
seq num:  ..106       116  

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