triangle PDBeMotif: 1hxy  
  coner Sequences coner   coner 3D motifs coner   coner Ligand environment coner   coner Ligand bonds coner
   
coner
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coner
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Classification immune system/toxin    | release date: Wed, Jan 17, 2001
Title crystal structure of staphylococcal enterotoxin h in complex with human mhc class ii
Authors A.LILJAS, B.WALSE, G.FORSBERG, H.NILSSON, K.PETERSSON, L.A.SVENSSON, M.HAKANSSON
Method X-RAY DIFFRACTION (resolution: 2.60Å)
PDBe Citation   
Small molecules:    search ZN ZN binding statistics ZN
Ligand bond colours:   *  covalent   *  ionic   *  hydrogen   *  electrostatic   *  van-der-waals   *  plane-atom   *  plane-plane   *  undefined  - Click here to show 5Å bonds
Chain A sequence:
IKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYT
PITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDV
YDCRVEHWGLDEPLLKHWEFDA
Chain B sequence:
GDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCR
HNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVM
LETVPRSGEVYTCQVEHPSVTSPLTVEWRA
Chain C sequence:
PKYVKQNTLKLAT
Chain D sequence:
EDLHDKSELTDLALANAYGQYNHPFIKENIKSDEISGEKDLIFRNQGDSGNDLRVKFATADLAQKFKNKNVDIYGASFYY
KCEKISENISECLYGGTTLNSEKLAQERVIGANVWVDGIQKETELIRTNKKNVTLQELDIKIRKILSDKYKIYYKDSEIS
KGLIEFDMKTPRDYSFDIYDLKGENDYEIDKIYEDNKTLKSDDISHIDVNLYT
Residue colours:  hydrophilic   hydrophobic   intermediate 
Assembly 1     View the assembly/model: ( JMolViewer Download PDB file RasMol script viewer AstexViewer™@MSD-EBI )
Motif search   chain:    Sequence numbers: 
   Using:   φ/ψ    residues code    secondary structures   
 coordinates of:  Cαs Side-chain
 
      View the fragment: rasmol script JMol viewer
chain A : HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRALPHA CHAIN;
member of: CATH:search2.60.40.10/search3.10.320.10GENE3D:searchG3DSA_2.60.40.10/searchG3DSA_3.10.320.10PANTHER:searchPTHR19944/searchPTHR19944_SF27PFAM:searchPF00993/searchPF07654PROSITE PATTERNS:searchPS00290, PROSITE PROFILES:searchPS50835, SMART:searchSM00407/searchSM00920SUPERFAMILY:searchSSF48726/searchSSF54452UniProt:searchP01903
sec str:  ....eeeeeeeeeee...eeeeeeee..eeeeeee....eeee.hhhhhhh...hhhhhhhhhhhhhhhhhhhhhhh..........eeeeee.........eeeeeeeeee.....eeeeee..ee.....ee...ee.....eeeeeeeee......eeeeeee.......eeeeee...
sequence :  ..EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDA
seq num:  ..3         13        23        33        43        53        63        73        83        93        103       113       123       133       143       153       163       173       
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..              | |      |  |     | || ||    |  |  |     |    |      |   ||||||               |  |  |                ^*** |  |  | ||   |     | |           | || | |   |  |            
search RasMol script viewer Motif-ligand binding stats  CAMP_PHOSPHO_SITE ..              | |      |  |     | |**^*    |  |  |     |    |      |   ||||||               |  |  |                     |  |  | ||   |     | |           | || | |   |  |            
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..              | |      |  |     | || |     |  |  |     |    |      |   ^**|||               |  |  |                     |  |  | ||   |     | |           | || | |   |  |            
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..              | |      |  |     | || |     |  |  |     |    |      |   || |||               ^***  |                     |  |  | ||   |     | |           ^*** | |   |  |            
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..              | |      |  |     | || |     |  |  |     ^*****      |   || |||                  |  |                     |  |  | ^*****     | |           | || | |   |  |            
search RasMol script viewer Motif-ligand binding stats  IG_MHC ..              | |      |  |     | || |     |  |  |                 |   || |||                  |  |                     |  |  | ||         | |           | || **^****  |            
search RasMol script viewer Motif-ligand binding stats  asxturn ..              | |      |  |     ***| |     |  |  |                 |   || |||                  |  |                     |  |  | ||         ***           | ||       |  |            
search RasMol script viewer Motif-ligand binding stats  betaturn ..              | |      ****        | |     ****  |                 |   |****|                  |  |                     ****  | ||         | |           | ||       |  |            
search RasMol script viewer Motif-ligand binding stats  gammaturn ..              | |                  | |        |  |                 |   |  | |                  |  |                           ***|         | |           | ||       |  |            
search RasMol script viewer Motif-ligand binding stats  nest ..              ***                  ***        |  |                 |   |  ***                  |  |                           |  |         ***           | ||       |  |            
search RasMol script viewer Motif-ligand binding stats  niche ..                                              ****                 |   |    |                  ****                           ****                       ****       ****            
search RasMol script viewer Motif-ligand binding stats  schellmannloop ..                                                                   |   ******                                                                            | |                        
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                                                   *****                                                                                 | |                        
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                                                                                                                         ***                        

chain B : HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1BETA CHAIN;
member of: CATH:search2.60.40.10/search3.10.320.10GENE3D:searchG3DSA_2.60.40.10/searchG3DSA_3.10.320.10PANTHER:searchPTHR19944/searchPTHR19944_SF42PFAM:searchPF00969/searchPF07654PRODOM:searchPD000328PROSITE PATTERNS:searchPS00290, PROSITE PROFILES:searchPS50835, SMART:searchSM00407/searchSM00921SUPERFAMILY:searchSSF48726/searchSSF54452UniProt:searchP04229
JMol viewer RasMol script viewer  ZN 600D  ..                                                                              *                      ..                                                                               
sec str:  ......eeeeeeeeeeee....eeeeeeeeee..eeeeeee.....eee.hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh..........eeeee....eeeeeeeeee.....eeeeee..ee....eee...ee.....eeeeeeeee......eeeeeee.......eeeeee.
sequence :  ..TRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYP..HNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA
seq num:  ..3         13        23        33        43        53        63        73        83        93         ..112       122       132       142       152       162       172       182      
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..                ^***| |      |    | | | |||||   | ||  ||    ||||||               | |  ||  |          ..       |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..                  ^** |      |    ^** | |||||   | ||  ||    ^**|||               | |  ||  |          ..       |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..                      |      |      | | |||||   | ||  ||    ^***||               | |  ||  |          ..       |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  TYR_PHOSPHO_SITE ..                      *******^      ********^   | ||  ||     |  ||               | |  ||  |          ..       |  | | |           ||||| | |   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..                                      | ||||    | ||  ||     |  ||               ^*****|  |          ..       |  | | |           |||^*****   |||||           |  | | |   |  |          
search RasMol script viewer Motif-ligand binding stats  IG_MHC ..                                      | ||||    | ||  ||     |  ||                 |   |  |          ..       |  | | |           ||| | | |   |||||           |  | **^****  |          
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..                                      *****|    | |*****     *****                 |   |  |          ..       |  | | |           ||| | | |   |||||           |  |       |  |          
search RasMol script viewer Motif-ligand binding stats  asxmotif ..                                      *****|    | ||  |      |  |                  |   |  |          ..       |  | | |           ||| | | |   |||||           |  |       |  |          
search RasMol script viewer Motif-ligand binding stats  asxturn ..                                      ***| |    | ||  |      |  |                  |   |  |          ..       |  | | |           ||| | | |   ||***           |  |       |  |          
search RasMol script viewer Motif-ligand binding stats  betaturn ..                                      **** |    | |****      ****                  |   |  |          ..       |  | | |           ||| | | |   |||||           |  |       ****          
search RasMol script viewer Motif-ligand binding stats  nest ..                                         ***    | |                                |   |  |          ..       |  | | |           ||| | | |   *****           |  |       |  |          
search RasMol script viewer Motif-ligand binding stats  niche ..                                                | |                                |   ****          ..       **** ***           ***** | |                   ****       ****          
search RasMol script viewer Motif-ligand binding stats  ststaple ..                                                | |                                *****             ..                                | |                                            
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                ***                                                  ..                                ***                                            

chain C : HEMAGGLUTININ
member of: GB:search6470273GENE3D:searchG3DSA_2.10.77.10PFAM:searchPF00509PRINTS:searchHEMAGGLUTN1/searchHEMAGGLUTN12SUPERFAMILY:searchSSF49818UniProt:searchQ03909
sec str:  ...............
sequence :  ..PKYVKQNTLKLAT
seq num:  ..306          
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..       ^**   

chain D : ENTEROTOXIN H
member of: CATH:search2.40.50.110/search3.10.20.120GENE3D:searchG3DSA_2.40.50.110/searchG3DSA_3.10.20.120PFAM:searchPF01123/searchPF02876PRINTS:searchBACTRLTOXIN/searchSAGSUPRFAMLYPROSITE PATTERNS:searchPS00278, SUPERFAMILY:searchSSF50203/searchSSF54334UniProt:searchP0A0M0
JMol viewer RasMol script viewer  ZN 600D  ..                                                                                                                                                                                                            * *     
sec str:  .....hhhhhhhhhhhhhhhhhhh.eeeeee.........eeee...hhhhheeeee..hhhhhhhhh...eeeee.ee...........eeeee..eee...eeeeeeeeeeeeee..ee...eeeeeee.eeehhhhhhhhhhhhhhhhh.........eeeeeeee....eeeee.......hhhhhhhhhh...eee...eeeeeeeee.
sequence :  ..DLHDKSELTDLALANAYGQYNHPFIKENIKSDEISGEKDLIFRNQGDSGNDLRVKFATADLAQKFKNKNVDIYGASFYYKCEKISENISECLYGGTTLNSEKLAQERVIGANVWVDGIQKETELIRTNKKNVTLQELDIKIRKILSDKYKIYYKDSEISKGLIEFDMKTPRDYSFDIYDLKGENDYEIDKIYEDNKTLKSDDISHIDVNLYT
seq num:  ..2         12        22        32        42        52        62        72        82        92        102       112       122       132       142       152       162       172       182       192       202         
search RasMol script viewer Motif-ligand binding stats  ASN_GLYCOSYLATION ..   ||| |                            | |    | | |  |           | || |         |  |   | ^***    |    | |                        | | ^*** ||        | ||||||  | |||      | | ||   | ||| | |  ||     |^***|| |||| |     
search RasMol script viewer Motif-ligand binding stats  PKC_PHOSPHO_SITE ..   ||| |                            | |    | | |  |           | || |         |  |   | |       |    ^**                        ^**   |  ||        ^**|||||  | |||      | ^**|   | ||| | |  ||     | |^**| |||| |     
search RasMol script viewer Motif-ligand binding stats  CK2_PHOSPHO_SITE ..   ||| |                            | |    | | ^***           | || |         |  |   | |       |    |                          | |   ^***|           |||||  | |||      | ^***   | ||| | |  ||     | |  || ||^***     
search RasMol script viewer Motif-ligand binding stats  MYRISTYL ..   ||| |                            | |    | |                | || |         |  |   | |       ^*****                          | |   |   |           |||||  | |||      | | |    | ||| | |  ||     | |  || ||||       
search RasMol script viewer Motif-ligand binding stats  STAPH_STREP_TOXIN_2 ..   ||| |                            | |    | |                | || |         |  |   | |                                       | ************************|  | |||      | | |    | ||| | |  ||     | |  || ||||       
search RasMol script viewer Motif-ligand binding stats  alphabetamotif ..   ||| |                            | |    | |                | || |         |  |   | |                                       | |   |   |           |||||  | |||      | | |    | ||| | *****     | |  *****||       
search RasMol script viewer Motif-ligand binding stats  asxmotif ..   ||| |                            | |    | |                | || |         |  |   | |                                       | |   |   |           |||||  | |||      | | |    ***** | |  |      | |  || ||||       
search RasMol script viewer Motif-ligand binding stats  asxturn ..   *** |                            | |    | |                | || |         |  |   | |                                       | |   |   |           |||||  | |||      | | |    ***|  | |  |      | |  || ||||       
search RasMol script viewer Motif-ligand binding stats  betabulge ..    |  |                            | |    | |                | || |         |  |   | |                                       | |   |   |           |||||  | |**      | | |    |  |  | |  |      | |  || ||**       
search RasMol script viewer Motif-ligand binding stats  betaturn ..    |  |                            | |    | |                ******         ****   | |                                       | |   |   |           |||||  | |        | | |    ****  | ****      | |  ****|         
search RasMol script viewer Motif-ligand binding stats  gammaturn ..    |  |                            | |    | |                | || |         |  |   | |                                       | |   |   |           |||||  | |        | ***          | |         | |   |  |         
search RasMol script viewer Motif-ligand binding stats  nest ..    |  |                            ***    ***                | || |         |  |   | |                                       | |   |   |           ****|  | |        | | |          | |         ***   |  |         
search RasMol script viewer Motif-ligand binding stats  niche ..    ****                                   ***                ******         ****   ***                                       ***   |   |            ****  ***        *****          ***               ****         
search RasMol script viewer Motif-ligand binding stats  stmotif ..                                                                                                                              | |   *****                                                                           
search RasMol script viewer Motif-ligand binding stats  stturn ..                                                                                                                              ***                                                                                   

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