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UniProtKB/Swiss-Prot & UniProtKB/TrEMBL Publications
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Figure
1. A sample entry from Swiss-Prot |
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ID TNF5_HUMAN STANDARD; PRT; 261 AA.
AC P29965;
DT 01-APR-1993 (Rel. 25, Created)
DT 01-APR-1993 (Rel. 25, Last sequence update)
DT 15-JUL-1999 (Rel. 38, Last annotation update)
DE CD40 LIGAND (CD40-L) (TNF-RELATED ACTIVATION PROTEIN) (TRAP) (T CELL
DE ANTIGEN GP39) (CD154 ANTIGEN).
GN TNFSF5 OR CD40LG OR CD40L OR TRAP.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 93076854.
RA GRAF D., KORTHAEUER U., MAGES H.W., SENGER G., KROCZEK R.A.;
RT "Cloning of TRAP, a ligand for CD40 on human T cells.";
RL Eur. J. Immunol. 22:3191-3194(1992).
.. 6 references omitted
..
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 116-261.
RX MEDLINE; 96131874.
RA KARPSUSAS M., HSU Y.-M., WANG J.-H., THOMPSON J., LEDERMAN S.,
RA CHESS L., THOMAS D.;
RT "2-A crystal structure of an extracellular fragment of human CD40
RT ligand.";
RL Structure 3:1031-1039(1995).
RN [8]
RP 3D-STRUCTURE MODELING OF COMPLEX WITH CD40.
RX MEDLINE; 98266353.
RA SINGH J., GARBER E., VAN VLIJMEN H., KARPSUSAS M., HSU Y.-M.,
RA ZHENG Z., NAISMITH J.H., THOMAS D.;
RT "The role of polar interactions in the molecular recognition of CD40L
RT with its receptor CD40.";
RL Protein Sci. 7:1124-1135(1998).
RN [9]
.. 6 references omitted
..
RN [14]
RP VARIANTS HIGM1 ARG-36; CYS-140; SER-231; MET-254 AND GLY-227 DEL.
RX MEDLINE; 97295077.
RA NONOYAMA S., SHIMADZU M., TORU H., SEYAMA K., NUNOI H., NEUBAUER M.,
RA YATA J.-I., OCH H.D.;
RT "Mutations of the CD40 ligand gene in 13 Japanese patients with
RT X-linked hyper-IgM syndrome.";
RL Hum. Genet. 99:624-627(1997).
CC -!- FUNCTION: MEDIATES B-CELL PROLIFERATION IN THE ABSENCE OF CO-
CC STIMULUS AS WELL AS IGE PRODUCTION IN THE PRESENCE OF IL-4.
CC INVOLVED IN IMMUNOGLOBULIN CLASS SWITCHING.
CC -!- SUBUNIT: HOMOTRIMER.
CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. ALSO EXISTS AS AN
CC EXTRACELLULAR SOLUBLE FORM.
CC -!- TISSUE SPECIFICITY: SPECIFICALLY EXPRESSED ON ACTIVATED CD4+
CC T-LYMPHOCYTES.
CC -!- DISEASE: DEFECTS IN CD40LG ARE THE CAUSE OF AN X-LINKED
CC IMMUNODEFICIENCY WITH HYPER-IGM (HIGM1), AN IMMUNOGLOBULIN ISOTYPE
CC SWITCH DEFECT CHARACTERIZED BY ELEVATED CONCENTRATIONS OF SERUM
CC IGM AND DECREASED AMOUNTS OF ALL OTHER ISOTYPES. AFFECTED MALES
CC PRESENT AT AN EARLY AGE (USUALLY WITHIN THE FIRST YEAR OF LIFE)
CC RECURRENT BACTERIAL AND OPPORTUNISTIC INFECTIONS, INCLUDING
CC PNEUMOCYSTIS CARINII PNEUMONIA AND INTRACTABLE DIARRHEA DUE TO
CC CRYPTOSPORIDIUM INFECTION. DESPITE SUBSTITUTION TREATMENT WITH
CC INTRAVENOUS IMMUNOGLOBULIN, THE OVERALL PROGNOSIS IS RATHER POOR,
CC WITH A DEATH RATE OF ABOUT 10% BEFORE ADOLESCENCE.
CC -!- SIMILARITY: BELONGS TO THE TUMOR NECROSIS FACTOR FAMILY.
CC -!- DATABASE: name=CD40Lbase;
CC NOTE=European CD40L defect database (mutation db);
CC WWW="http://www.expasy.ch/cd40lbase/";
CC FTP="ftp://ftp.expasy.ch/databases/cd40lbase".
CC -!- DATABASE: name=PROW; NOTE=CD guide CD154 entry;
CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd154.htm".
DR EMBL; X68550; CAA48554.1; -.
DR EMBL; Z15017; CAA78737.1; -.
DR EMBL; X67878; CAA48077.1; -.
DR EMBL; L07414; AAA35662.1; -.
DR EMBL; D31797; BAA06599.1; -.
DR EMBL; D31793; BAA06599.1; JOINED.
DR EMBL; D31794; BAA06599.1; JOINED.
DR EMBL; D31795; BAA06599.1; JOINED.
DR EMBL; D31796; BAA06599.1; JOINED.
DR PIR; S25684; S25684.
DR PIR; S26694; S26694.
DR PIR; S28017; S28017.
DR PIR; S28852; S28852.
DR PIR; JH0793; JH0793.
DR PDB; 1ALY; 17-SEP-97.
DR MIM; 308230; -.
DR PFAM; PF00229; TNF; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
KW Cytokine; Transmembrane; Glycoprotein; Signal-anchor; 3D-structure;
KW Disease mutation; Polymorphism.
FT DOMAIN 1 22 CYTOPLASMIC (POTENTIAL).
FT TRANSMEM 23 46 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN).
FT DOMAIN 47 261 EXTRACELLULAR (POTENTIAL).
FT DISULFID 178 218 POTENTIAL.
FT CARBOHYD 240 240 POTENTIAL.
FT VARIANT 36 36 M -> R (IN H1GM1).
FT VARIANT 123 123 A -> E (IN H1GM1).
FT VARIANT 126 126 V -> A (IN H1GM1).
FT VARIANT 128 129 SE -> RG (IN H1GM1).
FT VARIANT 140 140 W -> C (IN H1GM1).
FT VARIANT 140 140 W -> G (IN H1GM1).
FT VARIANT 140 140 W -> R (IN H1GM1).
FT VARIANT 144 144 G -> E (IN H1GM1).
FT VARIANT 155 155 L -> P (IN H1GM1).
FT VARIANT 211 211 T -> D (IN H1GM1).
FT VARIANT 219 219 G -> R.
FT VARIANT 227 227 G -> V (IN H1GM1).
FT VARIANT 227 227 MISSING (IN H1GM1).
FT VARIANT 231 231 L -> S (IN H1GM1).
FT VARIANT 235 235 A -> P (IN H1GM1).
FT VARIANT 254 254 T -> M (IN H1GM1).
SQ SEQUENCE 261 AA; 29273 MW; DC2AD21F CRC32;
MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL DKIEDERNLH
EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML NKEETKKENS FEMQKGDQNP
QIAAHVISEA SSKTTSVLQW AEKGYYTMSN NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN
REASSQAPFI ASLCLKSPGR FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN
VTDPSQVSHG TGFTSFGLLK L
//
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Figure
2. A sample entry from TrEMBL |
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ID Q31795 PRELIMINARY; PRT; 475 AA.
AC Q31795;
DT 01-NOV-1996 (TrEMBLrel. 01, Created)
DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update)
DT 01-SEP-1999 (TrEMBLrel. 12, Last annotation update)
DE RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN (EC 4.1.1.39).
GN RBCL.
OS Anthoceros formosae.
OG Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Anthocerotopsida;
OC Anthocerotales; Anthocerotaceae; Anthoceros.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 96184846.
RA YOSHINAGA K., IINUMA H., MASUZAWA T., UEDA K.;
RT "Extensive RNA editing of U to C in addition to C to U substitution
RT in the rbcL transcripts of hornwort chloroplasts and the origin of
RT RNA editing in green plants.";
RL Nucleic Acids Res. 24:1008-1014(1996).
CC -!- FUNCTION: RUBISCO CATALYSES TWO REACTIONS: THE CARBOXYLATION OF D-
CC RIBULOSE 1,5-BISPHOSPHATE, THE PRIMARY EVENT IN PHOTOSYNTHETIC
CC CARBON DIOXIDE FIXATION, AS WELL AS THE OXIDATIVE FRAGMENTATION OF
CC THE PENTOSE SUBSTRATE IN THE PHOTORESPIRATION PROCESS. BOTH
CC REACTIONS OCCUR SIMULTANEOUSLY AND IN COMPETITION AT THE SAME
CC ACTIVE SITE.
CC -!- CATALYTIC ACTIVITY: D-RIBULOSE 1,5-BISPHOSPHATE + CO(2) = 2 3-
CC PHOSPHO-D-GLYCERATE.
CC -!- CATALYTIC ACTIVITY: D-RIBULOSE 1,5-BISPHOSPHATE + O(2) = 3-
CC PHOSPHO-D-GLYCERATE + 2-PHOSPHOGLYCOLATE.
CC -!- SUBUNIT: 8 LARGE CHAINS + 8 SMALL CHAINS.
CC -!- SUBCELLULAR LOCATION: CHLOROPLAST.
DR EMBL; D43695; BAA07796.1; -.
DR PROSITE; PS00157; RUBISCO_LARGE; 1.
DR PFAM; PF00016; RuBisCO_large; 1.
DR MENDEL; 21614; Antfo;rbcL;21614.
KW Chloroplast; Photosynthesis; Carbon dioxide fixation;
KW Photorespiration; Lyase; Oxidoreductase; Monooxygenase.
FT ACT_SITE 202 202 BINDING OF CO(2) ACTIVATES THE ENZYME.
SQ SEQUENCE 475 AA; 52352 MW; FEE98D6C CRC32;
MSPQTETKAG VGFKAGVKDY RLTHYTPDYE TKDTDILAAS XMTPXPGVPP EEAGAAVAAE
SSTGTWTTVW TDGLTSLDRY KGRCYDIEPV AGEENQYIAY AAYSLDLFEE GSVTNMFTSI
VGNVFGFKAL RASRLEDSRI PPAYSKTFQG PPHGIQVERD KSNKYGRPLL GCTIKPKLGL
SAKNYGRAVY ECLRGGLDFT KDDENVNSQP FMRWRDRFLF VAEAISKSQA ETGEIKGHYL
NATAGTCEEM MKRAHFAREL GMPIVMHDYL TGGFIANTTL ARYCRDNGLL LHIHRAMHAV
TDRQRNHGIH FRVSAKASRM SGGDHIHPGT VVGKLEGECE VTLGFVDLPC DDYIEKDRSR
GIYFTQDWVS MPGVLLVASG GIHVWHMPAL TEIFGDDSVL QFGGGTLGHP WGNAPGAVAN
RVALEACVQA RNEGRDLARE GNDIIREASK WSPELAAACE VWKEIKFVFE TIDTL
//
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Figure
3. The Production of TrEMBL |
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Figure
4. First level TrEMBLnew entries (after translation
and entry creation) |
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ID AAC51357 PRELIMINARY; PRT; 440 AA.
AC AAC51357;
DT 31-JUN-1997 (EMBLrel. 51, Created)
DT 31-JUN-1997 (EMBLrel. 51, Last sequence update)
DT 31-JUN-1997 (EMBLrel. 51, Last annotation update)
DE GABA-A RECEPTOR PI SUBUNIT.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A.
RA HEDBLOM E., KIRKNESS E.F.;
RT "A novel class of GABAA receptor subunit in tissues of the
RT reproductive system.";
RL J. Biol. Chem. 272:15346-15350(1997).
DR EMBL; U95367; AAC51357.1; -.
SQ SEQUENCE 440 AA; 50640 MW; 375043BA CRC32;
MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS
SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL
LFPLIFMLAN VFYWAYYMYF
//
ID AAC24194 PRELIMINARY; PRT; 440 AA.
AC AAC24194;
DT 31-JUN-1997 (EMBLrel. 51, Created)
DT 31-JUN-1997 (EMBLrel. 51, Last sequence update)
DT 31-JUN-1997 (EMBLrel. 51, Last annotation update)
DE GABA-A RECEPTOR PI SUBUNIT.
GN GABRP.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A.
RA JOHNSON E.K., HEDBLOM E., KIRKNESS E.F.;
RT "Structure and localization of the gene encoding the human GABA-A
RT receptor pi subunit (GABRP).";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
DR EMBL; AF009702; AAC24194.1; -.
DR EMBL; AF009694; AAC24194.1; JOINED.
DR EMBL; AF009695; AAC24194.1; JOINED.
DR EMBL; AF009696; AAC24194.1; JOINED.
DR EMBL; AF009697; AAC24194.1; JOINED.
DR EMBL; AF009698; AAC24194.1; JOINED.
DR EMBL; AF009699; AAC24194.1; JOINED.
DR EMBL; AF009700; AAC24194.1; JOINED.
DR EMBL; AF009701; AAC24194.1; JOINED.
SQ SEQUENCE 440 AA; 50640 MW; 375043BA CRC32;
MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS
SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL
LFPLIFMLAN VFYWAYYMYF
//
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Figure
5. Second level TrEMBLnew entry (after merging) |
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ID AAC51357 PRELIMINARY; PRT; 440 AA.
AC AAC51357;
DT 31-JUN-1997 (EMBLrel. 51, Created)
DT 31-JUN-1997 (EMBLrel. 51, Last sequence update)
DT 31-JUN-1997 (EMBLrel. 51, Last annotation update)
DE GABA-A RECEPTOR PI SUBUNIT.
GN GABRP.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A.
RA HEDBLOM E., KIRKNESS E.F.;
RT "A novel class of GABAA receptor subunit in tissues of the
RT reproductive system.";
RL J. Biol. Chem. 272:15346-15350(1997).
RN [2]
RP SEQUENCE FROM N.A.
RA JOHNSON E.K., HEDBLOM E., KIRKNESS E.F.;
RT "Structure and localization of the gene encoding the human GABA-A
RT receptor pi subunit (GABRP).";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
DR EMBL; U95367; AAC51357.1; -.
DR EMBL; AF009702; AAC24194.1; -.
DR EMBL; AF009694; AAC24194.1; JOINED.
DR EMBL; AF009695; AAC24194.1; JOINED.
DR EMBL; AF009696; AAC24194.1; JOINED.
DR EMBL; AF009697; AAC24194.1; JOINED.
DR EMBL; AF009698; AAC24194.1; JOINED.
DR EMBL; AF009699; AAC24194.1; JOINED.
DR EMBL; AF009700; AAC24194.1; JOINED.
DR EMBL; AF009701; AAC24194.1; JOINED.
SQ SEQUENCE 440 AA; 50640 MW; 375043BA CRC32;
MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS
SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL
LFPLIFMLAN VFYWAYYMYF
//
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Figure
6. Third level TrEMBLnew entriy (after complete post-processing):
SP-TrEMBL |
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ID O00591 PRELIMINARY; PRT; 440 AA.
AC O00591;
DT 01-JUL-1997 (TrEMBLrel. 04, CREATED)
DT 01-JUL-1997 (TrEMBLrel. 04, LAST SEQUENCE UPDATE)
DT 01-JUL-1997 (TrEMBLrel. 04, LAST ANNOTATION UPDATE)
DE GABA-A RECEPTOR PI SUBUNIT.
GN GABRP.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 97326112.
RA HEDBLOM E., KIRKNESS E.F.;
RT "A novel class of GABAA receptor subunit in tissues of the
RT reproductive system.";
RL J. Biol. Chem. 272:15346-15350(1997).
RN [2]
RP SEQUENCE FROM N.A.
RA JOHNSON E.K., HEDBLOM E., KIRKNESS E.F.;
RT "Structure and localization of the gene encoding the human GABA-A
RT receptor pi subunit (GABRP).";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (BY SIMILARITY).
CC -!- SIMILARITY: BELONGS TO THE LIGAND-GATED IONIC CHANNELS FAMILY.
DR EMBL; U95367; AAC51357.1; -.
DR EMBL; AF009702; AAC24194.1; -.
DR EMBL; AF009694; AAC24194.1; JOINED.
DR EMBL; AF009695; AAC24194.1; JOINED.
DR EMBL; AF009696; AAC24194.1; JOINED.
DR EMBL; AF009697; AAC24194.1; JOINED.
DR EMBL; AF009698; AAC24194.1; JOINED.
DR EMBL; AF009699; AAC24194.1; JOINED.
DR EMBL; AF009700; AAC24194.1; JOINED.
DR EMBL; AF009701; AAC24194.1; JOINED.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
DR PFAM; PF00065; neur_chan; 2.
KW Postsynaptic membrane; Ionic channel; Glycoprotein; Transmembrane.
SQ SEQUENCE 440 AA; 50640 MW; 375043BA CRC32;
MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS
SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL
LFPLIFMLAN VFYWAYYMYF
//
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Figure
7. A fully annotated Swiss-Prot entry: The ultimate
fate of a TrEMBLnew entry |
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ID GAAP_HUMAN STANDARD; PRT; 440 AA.
AC O00591;
DT 15-JUL-1999 (Rel. 38, Created)
DT 15-JUL-1999 (Rel. 38, Last sequence update)
DT 15-DEC-1999 (Rel. 39, Last annotation update)
DE GAMMA-AMINOBUTYRIC-ACID RECEPTOR PI SUBUNIT PRECURSOR (GABA(A)
DE RECEPTOR).
GN GABRP.
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 97326112.
RA HEDBLOM E., KIRKNESS E.F.;
RT "A novel class of GABAA receptor subunit in tissues of the
RT reproductive system.";
RL J. Biol. Chem. 272:15346-15350(1997).
RN [2]
RP SEQUENCE FROM N.A.
RA JOHNSON E.K., HEDBLOM E., KIRKNESS E.F.;
RT "Structure and localization of the gene encoding the human GABA-A
RT receptor pi subunit (GABRP).";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GABA, THE MAJOR INHIBITORY NEUROTRANSMITTER IN THE
CC VERTEBRATE BRAIN, MEDIATES NEURONAL INHIBITION BY BINDING TO THE
CC GABA/BENZODIAZEPINE RECEPTOR AND OPENING AN INTEGRAL CHLORIDE
CC CHANNEL. IN THE UTERUS, THE FUNCTION OF THE RECEPTOR APPEARS TO BE
CC RELATED TO TISSUE CONTRACTILITY. THE BINDING OF THIS PI SUBUNIT
CC WITH OTHER GABA(A) RECEPTOR SUBUNITS ALTERS THE SENSITIVITY OF
CC RECOMBINANT RECEPTORS TO MODULATORY AGENTS SUCH AS PREGNANOLONE.
CC -!- SUBUNIT: GENERALLY PENTAMERIC. THERE ARE FIVE TYPES OF GABA(A)
CC RECEPTOR CHAINS: ALPHA, BETA, GAMMA, DELTA, AND EPSILON. A SIXTH
CC CLASS OF SUBUNIT: RHO FORM HOMOMERIC GABA RECEPTORS THAT DO NOT
CC APPEAR TO COEXIST WITH GABA(A) RECEPTOR SUBUNITS BUT WITH GABA(C)
CC RECEPTOR SUBUNITS. SUBUNIT PI CAN ALSO BIND THIS COMPLEX.
CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC -!- TISSUE SPECIFICITY: MOST ABUNDANT IN THE UTERUS, ALSO EXPRESSED IN
CC LUNG, THYMUS AND PROSTATE.
CC -!- SIMILARITY: BELONGS TO THE LIGAND-GATED IONIC CHANNELS FAMILY.
CC -----------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a
CC collaboration between the Swiss Institute of Bioinformatics and the
CC EMBL outstation - the European Bioinformatics Institute. There are no
CC restrictions on its use by non-profit institutions as long as its
CC content is in no way modified and this statement is not removed. Usage
CC by and for commercial entities requires a license agreement (See
CC http://www.isb-sib.ch/announce/ or send an email to
CC license@isb-sib.ch).
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DR EMBL; U95367; AAC51357.1; -.
DR EMBL; AF009702; AAC24194.1; -.
DR EMBL; AF009694; AAC24194.1; JOINED.
DR EMBL; AF009695; AAC24194.1; JOINED.
DR EMBL; AF009696; AAC24194.1; JOINED.
DR EMBL; AF009697; AAC24194.1; JOINED.
DR EMBL; AF009698; AAC24194.1; JOINED.
DR EMBL; AF009699; AAC24194.1; JOINED.
DR EMBL; AF009700; AAC24194.1; JOINED.
DR EMBL; AF009701; AAC24194.1; JOINED.
DR MIM; 602729; -.
DR PFAM; PF00065; neur_chan; 2.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
KW Postsynaptic membrane; Ionic channel; Glycoprotein; Signal;
KW Multigene family; Transmembrane.
FT SIGNAL 1 16 POTENTIAL.
FT CHAIN 17 440 GAMMA-AMINOBUTYRIC-ACID RECEPTOR PI
FT SUBUNIT.
FT DOMAIN 17 242 EXTRACELLULAR (PROBABLE).
FT TRANSMEM 243 266 PROBABLE.
FT TRANSMEM 270 292 PROBABLE.
FT TRANSMEM 305 327 PROBABLE.
FT DOMAIN 328 416 CYTOPLASMIC (PROBABLE).
FT TRANSMEM 417 438 PROBABLE.
FT DISULFID 160 174 BY SIMILARITY.
FT CARBOHYD 43 43 POTENTIAL.
FT CARBOHYD 102 102 POTENTIAL.
FT CARBOHYD 145 145 POTENTIAL.
FT CARBOHYD 196 196 POTENTIAL.
FT CARBOHYD 228 228 POTENTIAL.
SQ SEQUENCE 440 AA; 50640 MW; 375043BA CRC32;
MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP
VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT
YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES
WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR
NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS
SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL
LFPLIFMLAN VFYWAYYMYF
//
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Figure
8. EDITtoTrEMBL
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Figure
9. A sample entry from GCRDb |
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###GCR_0087 HSPLMERE X13556 421 SEROTONIN A GENOMIC
DATE_ADDED 930711
DATE_MOD 980128
FAMILY A
GROUP 2
IUPHAR 5HT1A-5-Hydroxytrptamine receptor
ABBREV 5HT1A
SPECIES Homo sapiens
UNIQ Y Y Y M Y Y 39 Y Y
REF%K Human gene for plasma membrane receptor
REF%K GB X13556
REF%K G-protein coupled receptor; glycoprotein; membrane protein;
REF%K human
REF%A B. K. Kobilka
REF%A T. Frielle
REF%A S. Collins
REF%A T. Feng
REF%A T. S. Kobilka
REF%A U. Francke
REF%A R. J. Lefkowitz
REF%A M. G. Caron
REF%T An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins
REF%J Nature
REF%V 329
REF%P 75-79
REF%D 1987
>HSPLMERE X13556, 421 bases, 47192D6F
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCA
VLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN
KWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTP
RPRALISLTWLIGFLISIPPILGWRTPEDRSDPDACTISKDHGYTIYSTF
GAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPK
KSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNS
KEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIM
GTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYA
YFNKDFQNAFKKIIKCNFCRQ
ORF173..1438
tgctcctcgg agataccctt cgccgaagca gtaagaactt cctgcttggg tctctgcatt
cccttcctcc gaaacttccc aggagaaggg cggaagaccc caggggaagg ggcgaggcga
atcttcgcgc tgctttttct tccctccccc ttcccgcgcc gggcgcgcag gcatggatgt
gctcagccct ggtcagggca acaacaccac atcaccaccg gctccctttg agaccggcgg
caacactact ggtatctccg acgtgaccgt cagctaccaa gtgatcacct ctctgctgct
gggcacgctc atcttctgcg cggtgctggg caatgcgtgc gtggtggctg ccatcgcctt
ggagcgctcc ctgcagaacg tggccaatta tcttattggc tctttggcgg tcaccgacct
catggtgtcg gtgttggtgc tgcccatggc cgcgctgtat caggtgctca acaagtggac
actgggccag gtaacctgcg acctgttcat cgccctcgac gtgctgtgct gcacctcatc
catcttgcac ctgtgcgcca tcgcgctgga caggtactgg gccatcacgg accccatcga
ctacgtgaac aagaggacgc cccggccgcg tgcgctcatc tcgctcactt ggcttattgg
cttcctcatc tctatcccgc ccatcctggg ctggcgcacc ccggaagacc gctcggaccc
cgacgcatgc accattagca aggatcatgg ctacactatc tattccacct ttggagcttt
ctacatcccg ctgctgctca tgctggttct ctatgggcgc atattccgag ctgcgcgctt
ccgcatccgc aagacggtca aaaaggtgga gaagaccgga gcggacaccc gccatggagc
atctcccgcc ccgcagccca agaagagtgt gaatggagag tcggggagca ggaactggag
gctgggcgtg gagagcaagg ctgggggtgc tctgtgcgcc aatggcgcgg tgaggcaagg
tgacgatggc gccgccctgg aggtgatcga ggtgcaccga gtgggcaact ccaaagagca
cttgcctctg cccagcgagg ctggtcctac cccttgtgcc cccgcctctt tcgagaggaa
aaatgagcgc aacgccgagg cgaagcgcaa gatggccctg gcccgagaga ggaagacagt
gaagacgctg ggcatcatca tgggcacctt catcctctgc tggctgccct tcttcatcgt
ggctcttgtt ctgcccttct gcgagagcag ctgccacatg cccaccctgt tgggcgccat
aatcaattgg ctgggctact ccaactctct gcttaacccc gtcatttacg catacttcaa
caaggacttt caaaacgcgt ttaagaagat cattaagtgt aacttctgcc gccagtgatg
acggaggagt agccggccag tcgaggctac aggatccgtc ccattcacta tgcttccccc
aaccctaggg aatccacact taatataatt cgccacttct cctctttttc tctgctccgc
tcacggcttg cagacctgg
EXN unknown
CHR unknown
TYP
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Figure
10. Representation of the InterPro data flow scheme,
illustrating the route from the source database providers
via the RDBMS to the end user. |
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