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rho-associated protein kinase

^ http://purl.obolibrary.org/obo/PR_000000024


A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an N-terminal Protein kinase domain (Pfam:PF00069), a Rho Binding domain (Pfam:PF08912), and a PH domain (Pfam:PF00169) and a Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130) at the C-terminus. Rho-associated protein kinases are mediators of many cellular processes by being effectors of the small GTP-binding protein Rho. [ PRO:CNA ]

Synonyms: RHO-ASSOCIATED, COILED-COIL CONTAINING PROTEIN KINASE (PTHR22988:SF3)

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