Hypothetical protein Sameer Velankar

Structural Genomics

Structural genomics projects aim to provide an experimental structure or a good model for every protein in all complete genomes. The term structural genomics is currently used to represent the efforts to obtain the structural complement of a genome or a particular cellular process. The many structural genomics initiatives around the world have started to bear fruit with new structures of proteins determined at an ever increasing rate. However, many of these proteins are of unknown function. 

Can structural knowledge enable us to answer questions about protein function? In this particular tutorial we will be looking at ways by which the MSD search tools can be used to answer questions relating to proteins whose structures have been determined but their function remains unknown.

PDB Entry 1J6P: CRYSTAL STRUCTURE OF CONSERVED HYPOTHETICAL PROTEIN(TM0936) FROM THERMOTOGA MARITIMA AT 1.9 A RESOLUTION

The title and various fields of this PDB entry were modified recently (Aug, 2004) to include the function of this protein. The title of this PDB entry now reflects the function of the protein we elucidated in this tutorial back in September 2003.