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CAPRI: Critical Assessment of PRediction of Interactions

Community wide experiment on the comparative evaluation of protein-protein docking for structure prediction

Hosted By EMBL/EBI-PDBe Group

We are announcing the imminent launch of CAPRI Round 47.

We are announcing CAPRI Round 47, the first Round of 2019, with target 160.

The protein is the assembly domain of SAP the surface layer (S-layer) protein from a highly pathogenic microbe. This assembly domain comprises 6 discrete structural domains, which self assemble into a 2D array whose structure is currently under study by Cryo-EM.

The 3D structure of the isolated SAP assembly domain in complex with two (different) nanobodies was solved to high resolution by X-ray diffraction (2 different crystal forms, displaying the same 3D fold of the SAP domain have been determined), and is being offered to CAPRI by Han Remaut and Antonella Floravanti from the VIB-VUB Center for Structural biology, in Brussels, Belgium.

This prediction challenge is particularly difficult, as it consists of modeling the 3D structure of the SAP assembly domain, as well as its complex with the 2 nanobodies. Taking on this challenge will move the community closer to integrating 3D structure predictions with assembly modeling!

We will evaluate separately the predicted 3D structure of the protein (e.g. intra- domain-domain interactions in particular) and the structure of the complexes (interfaces & contacts) with the 2 nanobodies. Given the difficulty of integrating the 3D structure and complex predictions, the deadlines for the server and predictor submissions will be extended.



Documentation and Targets Round 47


Target 160

  • Jan 22 - registration begins
  • Jan 28 - prediction Round opens
  • Feb 4 - deadline for server submissions
  • Mar 18 - deadline for submitting predictions
  • Mar 21 - scoring Round set available
  • Mar 28 - scoring Round submission deadline
In registering, please scrupulously adhere to the registration rules, according to which only team leaders, or teams (with identified members) can submit predictions.


SCORERS

Scorers can download the server set of submissions from
http://cb.iri.univ-lille1.fr/capri/ using the same login user/password as distributed for Capri round47. Full details and deadlines are given on this site.


Email Problems or Queries to Sameer Velankar

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