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CAPRI: Critical Assessment of PRediction of Interactions

Community wide experiment on the comparative evaluation of protein-protein docking for structure prediction

Hosted By EMBL/EBI-PDBe Group

Result (T131)

T131 featured HopQ-I bound to CEACAM1. There is only 1 medium-quality model in the top-5 submissions (and no acceptable ones).

Summary for T131

                    Predictor top            Scorer top
                    1    3    5   10  100    1    3    5   10 
  high              0    0    0    0    0    0    0    0    0 
  medium            0    0    1    1    2    1    1    1    3 
  acceptable        0    0    0    0    5    0    0    1    2 
  incorrect        27   81  135  274 1767   17   53   90  178 
  clashes/lowid     2    6    9   14  410    0    1    1    2 
  total            29   87  145  289 2184   18   55   93  185 

Link to result details: Result details

Result (T132)

T132 was the binding between HopQ-II (type II as opposed to type I for T131), which features as a dimer, with each monomer binding one CEACAM1, separately. Tthe target could therefore be reduced to one HopQ-II monomer binding one CEACAM1.

Most acceptable submissions could be found below the top-10 ranked models, but one medium-quality model was ranked 1st in the respective submission.

Summary for T132

                    Predictor top            Scorer top
                    1    3    5   10  100    1    3    5   10 
  high              0    0    0    0    0    0    0    0    0 
  medium            1    1    1    1    5    0    0    0    1 
  acceptable        0    1    1    4   27    0    2    4    8 
  incorrect        28   84  142  282 1769   19   51   82  163 
  clashes/lowid     1    4    6   12  474    0    3    5    9 
  total            30   90  150  299 2275   19   56   91  181 

Link to result details: Result details

ID mappings

Link ID for predictors: Predictors
Link ID for scorers: Scorers

Announcement

We are announcing the launch of CAPRI Round 42, with two x-ray structures of host-pathogen protein-protein hetero complexes of the cell adhesion protein CEACAM1 from human, with respectively, the cell adhesion proteins HopQ Type I, and HopQ Type II.

These targets are offered by Prof. Han Remaut (the Free University of Brussels, and the Vlaamse Institute voor Biotechnologie).

Detailed target information will be available when the prediction Round opens.

Please take note that the prediction timelines for this Round are particularly short in order to accommodate the authors’ publication schedule. There remains a remote possibility that the timelines may be extended to allow running the scoring challenge. Predictors are therefore requested to submit 100 models at the prediction deadline, as usual.

Documentation and Targets Round 42

  • Sep 25 - registration begins
Target T131 and T132
  • Oct 2 - prediction Round opens
  • Oct 4 - deadline for server submissions
  • Oct 16 - deadline for submitting predictions
  • Oct 18 - scoring Round set available (if author timing is extended)
  • Oct 25 - scoring Round submission deadline (if author timing is extended)

In registering, please scrupulously adhere to the registration rules, according to which only team leaders, or teams (with identified members) can submit predictions.


SCORERS

Scorers can download the server set of submissions from
http://cb.iri.univ-lille1.fr/capri/ using the same login user/password as distributed for Capri round42. Full details and deadlines are given on this site.


Email Problems or Queries to Sameer Velankar

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