Critical Assessment of PRediction of Interactions
Round 4 CAPRI community wide experiment on the comparative
evaluation of protein-protein docking for structure
Hosted By EMBL/EBI-MSD Group
There are 4 targets in CAPRI Round 4, Targets 11,12,13,14
Targets 11 and 12 are the same complex. In Target 11 (unbound),
one of the components appears as the NMR structure of a homolog;
in Target 12, it is given as the 'bound' molecule taken from the
complex. This should give you a chance to test homology docking
before doing the (certainly easier) unbound/bound Target 12 version.
It also implies that submissions of Target 11 predictions must end
before the 'bound' coordinates are made available to you.
NOTE: The structure for Target 10 the TBE trimer has
been published, see Bressanelli et al. (2004) EMBO J 23:728-738.
There are two independent copies of the trimer observed in the
asymmetric unit see 1URZ and
PQS page for PDB entry 1URZ
NOTE: The structures related to Targets 11 and 12 have now been
rpublished in PNAS PDB idcode 1ohz
The PDB entry 1ohz appears as a
hetero heaxmeric complex,
this however may be simply crystal packing, descrobed in the paper in
Figure 3. Alexandre Bonvin has also commented on the authors
discussion of the internal C2
symmetry of dockerin mentioning that it could bind in two orientations
(see Figure 5). He has suggested this may be taken into account for the
evaluation of the capri predictions, however this consideration was
to be unfeasible to carry out for the assessment.
The schedule will therefore be:
Sept 1: Round 4 opens for Targets 10, 11 and 13
Sept 21 midnight: Deadline for Target 11 submissions
Sept 22: Target 12 opens
Oct 12 midnight: Deadline for Target 10, 12 and 13 submissions
Documentation and Targets Round 4
Submissions are now closed
At the Evaluation Meeting, it was agreed that 10 models
can be submitted, and that they must be ranked.
Identification of Participants For Capri Round4 ID
The results are now available for targets 10, 11, 12 and 13.
NOTE THAT RESULTS HAVE BEEN RE-ACCESSED ON
JANUARY 07, 2005!!
Results for Target 10
Results for Target 11
Results for Target 12
Results for Target 13
Here are the Final Summary Files in ascii, the column headings are
as in the respective target FinalSummary.html files see links above
Final Summary Results for Target 10
Final Summary Results for Target 11
Final Summary Results for Target 12
Final Summary Results for Target 13
Email Problems or Queries to Kim
Henrick, John Tate