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CAPRI: Critical Assessment of PRediction of Interactions

Community wide experiment on the comparative evaluation of protein-protein docking for structure prediction

Hosted By EMBL/EBI-MSD Group

Round 24

Round 24 ID mapping from group number to Accessor Number for Target 50
Round 24 ID mapping from group number to Accessor Number for Target 51

NOTE The Coordinates for T50 are available for download. The structure is published ( PDB id code 3R2X)
NOTE The Coordinates for T51 not yet available for download

T50 result summary
T51 result summary

Target 50

Results T50 - click here to see the results

Scorer group S13 submitted one ** and 5 * models but unfortunately had to be disqualified since they failed to include the MD5 hash codes in their submission.

Full results:
Clash threshold 64.58
average 19.04
std dev 22.77


PredictorUploaderScorer
Nr groups 40 15 19
High Accuracy (***) 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Medium (**) 17 ( 10) 19 ( 3) 14 ( 6 <- 4)
Acceptable (*) 35 (15) 37 ( 7) 21 (11 <- 2)
Incorrect 289 (38) 1021 (13) 91 (12 <- 12)
Clashes 16 ( 6) 174 ( 4) 14 ( 4 <- 3)
Low ID 8 ( 1) 0 ( 0) 0 ( 0 <- 0)
Total 357 (39) 1251 (13) 140 (14 <- 13)


Numbers in parentheses refer to the number of different source groups producing these models (ie z scorer groups recognize y out of x uploader groups)


Target 51

Results T51.1 - click here to see the results

Results T51.2 - click here to see the results

Results T51.3 - click here to see the results

The target comprised modules GH5-CBM6-CBM13-Fn3-CBM62;GH5-CBM6 supplied as unpublished crystal structure, CBM13 to be built by homology from 1knl,Fn3 published as PDB 3mpc, CBM62 mobile in the crystal structure and can be ignored.

The single-chain target molecule was cut up into separate chains for each module for evaluation purposes as follows:
GH5 : residues 34 - 392
CBM6 : residues 393 - 516
CBM13 : residues 517 - 652
Fn3 : residues 653 - 739

Predictor structures were cut similarly based on largest sequence overlap with target chains, if necessary. Three separate assessments were performed:

T51.1 : CBM13/Fn3
Receptor - CBM13
Ligand - Fn3

T51.2 : GH5-CBM6/CBM13
Receptor - GH5-CBM6
Ligand - CMB13

T51.3 : GH5-CBM6/CBM13-Fn3
Receptor - GH5-CBM6
Ligand - CBM13-Fn3

Full results:
T51.1

Clash threshold 76.19
average 12.41
std dev 31.89


PredictorUploaderScorer
Nr groups 35 13 13
High Accuracy (***) 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Medium (**) 0 ( 0) 1 ( 1) 0 ( 0 <- 0)
Acceptable (*) 3 ( 2) 27 ( 4) 9 ( 4 <- 1)
Incorrect 242 (26) 920 (10) 111 (12 <- 2)
Clashes 23 ( 4) 24 ( 3) 0 ( 0 <- 0)
Low ID 37 ( 5) 28 ( 1) 0 ( 0 <- 0)
Total 305 (34) 1000 (10) 120 (12 <- 2)


Numbers in parentheses refer to the number of different source groups producing these models
(ie z scorer groups recognize y out of x uploader groups)



T51.2
Clash threshold 61.24
average 19.40
std dev 20.92


PredictorUploaderScorer
Nr groups 35 13 13
High Accuracy (***) 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Medium (**) 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Acceptable (*) 1 ( 1) 2 ( 2) 1 ( 1 <- 1)
Incorrect 232 (25) 724 ( 9) 100 (11 <- 10)
Clashes 40 (10) 182 ( 3) 16 ( 4 <- 4)
Low ID 32 ( 4) 0 ( 0) 0 ( 0 <- 0)
Total 305 (34) 908 (10) 117 (12 <- 11)



T51.3
Clash threshold 86.28
average 26.61
std dev 29.83


PredictorUploaderScorer
Nr groups 35 13 13
High Accuracy (***) 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Medium (**) 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Acceptable (*) 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Incorrect 228 (25) 758 ( 9) 103 (11 <- 11)
Clashes 20 ( 7) 190 ( 5) 17 ( 4 <- 4)
Low ID 0 ( 0) 0 ( 0) 0 ( 0 <- 0)
Total 248 (27) 948 (10) 120 (12 <- 12)
ROUND 24 Timeline
14th Feb 2011 - Registration opens for Round 24
21st Feb 2011 - Round 24 opens - Prediction of Target 50 and 51
20th March 2011 - Deadline for submitting models of 50 and 51
24th March 2011 - Scoring starts
27th March 2011 - Deadline for scoring submission


Target T50 a protein/protein complex

Target T51 a multidomain protein


Documentation and Targets Round 24

  • Participants
  • Management Group
  • Prediction formats
  • Download Opens 21st Feb 2011
  • Upload Opens 21st Feb 2011
  • Scoring download open 24th March 2011

  • Entries

  • Current submissions

  • SCORERS

    Scorers can download the server set of submissions from
    http://www.scmbb.ulb.ac.be/capri/ using the same login user/pass as distributed for Capri round24. Full details and deadlines are given on this site.


    Email Problems or Queries to Sameer Velankar

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