CAPRI: Critical Assessment of PRediction of Interactions

ROUND 26 RESULT ANNOUNCEMENT

ROUND 26 results for target 53 and 54 are now availabe

To download the target coordinates you must agree to the following conditions at the time of download.

Agreement (pdf)

To Register please email
Joel Janin, joel.janin@u-psud.fr, Sameer Velankar sameer@ebi.ac.uk
Send
Team Leader Name:
e-Mail Address:
Staff Position At your Institute:
If a Team is submitting
For each member please send Name: & email:

ROUND 26 ANNOUNCEMENT

New CAPRI ROUND 26

Protein-protein interactions and other interactions between macromolecules are essential to all aspects of biology and medical sciences, and a number of methods have been developed to predict them. CAPRI is a community wide experiment designed to assess those that are based on structure. If we know the 3D structure of two components of a complex and build a model of their assembly, how reliable and accurate is that model likely to be?

CAPRI is a blind prediction experiment managed by capri management . Its targets are unpublished crystal or NMR structures of complexes, communicated on a confidential basis by their authors to the CAPRI management. Participant predictor groups are given the atomic coordinates of two proteins that make biologically relevant interactions. They model the target complex with the help of the coordinates and other publicly available data (sequence, mutations etc~), and submit sets of ten models for assessment on the CAPRI Web site. In addition, the predictors are invited to upload larger sets that are communicated to scorer groups who evaluate and rank them, and make a separate ten-model submission. After the prediction round is completed, the CAPRI assessors compare the submissions to the experimental structure, et evaluate the models on criteria that depend on the geometry and biological relevance of the predicted interactions.

Since CAPRI began in 2001, the experiment has had two to four prediction rounds each year, with one or a few targets per round. Each round is announced a week in advance, it lasts 3-6 weeks, and the results are known in the following weeks. To be on the mailing list, please send a message to Sameer Velankar.

Structural biologists and scientists actively engaged in the study macromolecular interactions are invited to participate:
by offering targets -more information
by registering prediction rounds as predictors and/or scorers

Please read and observe the rules of the experiment and the confidentiality agreement that all CAPRI participants must sign.

Information on targets of past CAPRI rounds is available here

Capri Target Publications

Email Problems or Queries to Sameer Velankar