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CAPRI: Critical Assessment of PRediction of Interactions

CAPRI communitywide experiment on the comparative evaluation of protein-protein docking for structure prediction

Hosted by the Protein Data Bank in Europe (PDBe) Group

ROUND 31 ANNOUNCEMENT

  • 22nd Sep 2014 - Registration opens for Round 31
  • 29th Sep 2014 - Round 31 opens - Prediction of targets 95 (A challenging Enzyme-Nucleosome complex)
  • 13th Oct 2014 - Round 31 opens - Prediction of targets 96 (protein-protein complex)
  • 20th Oct 2014 - Round 31 opens - Prediction of targets 97 (protein-protein complex)
  • 13th Nov 2014 - Deadline for submitting models for target 95 (a protein-DNA-protein complex)
  • 15th Nov 2013 - Deadline for submitting models for targets 96-97 (protein-protein complexes)


  • ROUND 28 RESULT ANNOUNCEMENT

    ROUND 28 results for target 59 are now availabe




    To download the target coordinates you must agree to the following conditions at the time of download.

    Agreement (pdf)

    To Register please email
    Shashana Wodak - shoshana AT sickkids.ca, Sameer Velankar - sameer AT ebi.ac.uk
    Send
    Team Leader Name:
    e-Mail Address:
    Staff Position At your Institute:
    If a Team is submitting
    For each member please send Name: & email:

    Protein-protein interactions and other interactions between macromolecules are essential to all aspects of biology and medical sciences, and a number of methods have been developed to predict them. CAPRI is a community wide experiment designed to assess those that are based on structure. If we know the 3D structure of two components of a complex and build a model of their assembly, how reliable and accurate is that model likely to be?

    CAPRI is a blind prediction experiment managed by capri management . Its targets are unpublished crystal or NMR structures of complexes, communicated on a confidential basis by their authors to the CAPRI management. Participant predictor groups are given the atomic coordinates of two proteins that make biologically relevant interactions. They model the target complex with the help of the coordinates and other publicly available data (sequence, mutations etc~), and submit sets of ten models for assessment on the CAPRI Web site. In addition, the predictors are invited to upload larger sets that are communicated to scorer groups who evaluate and rank them, and make a separate ten-model submission. After the prediction round is completed, the CAPRI assessors compare the submissions to the experimental structure, et evaluate the models on criteria that depend on the geometry and biological relevance of the predicted interactions.

    Since CAPRI began in 2001, the experiment has had two to four prediction rounds each year, with one or a few targets per round. Each round is announced a week in advance, it lasts 3-6 weeks, and the results are known in the following weeks. To be on the mailing list, please send a message to Sameer Velankar.

    Structural biologists and scientists actively engaged in the study macromolecular interactions are invited to participate:
    by offering targets -more information
    by registering prediction rounds as predictors and/or scorers

    Please read and observe the rules of the experiment and the confidentiality agreement that all CAPRI participants must sign.

    Information on targets of past CAPRI rounds is available here

    Capri Target Publications


    CAPRI Special issues and Evaluation Meetings:


    Other publications:
    Welcome to CAPRI: A Critical Assessment of PRedicted Interactions Jol Janin, Proteins: Structure, Function, and Genetics Volume 47, Issue 3, 2002. Pages: 257 ( Local Copy: Call For Targets )
    Meeting Report. Modeling of protein interactions in genomes Sandor Vajda, Ilya A. Vakser, Michael J.E. Sternberg, Joel Janin, Proteins: Structure, Function, and Genetics Volume 47, Issue 4, 2002. Pages: 444-446 ( Local Copy: Meeting Report )
    Assessing predictions of protein-protein interaction: The CAPRI Experiment. J Janin (2005) Protein Sci. 14:278-283.
    The Third CAPRI Assessment Meeting, Toronto, Canada, April 20-21, 2007. J. Janin, SJ Wodak (2007) Structure 15, 755-759.


    Email Problems or Queries to Sameer Velankar

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