CAPRI communitywide experiment on the comparative evaluation of protein-protein docking for structure prediction
Hosted by the Protein Data Bank in Europe (PDBe) Group
We are announcing the launch of CAPRI Round 46. For more details on registration please see New CAPRI ROUND 46
SAVE THE DATE: The 7th CAPRI evaluation meeting will be held on April 3-5, 2019. For details please see 7th evaluation meeting page
To download the target coordinates you must agree to the
following conditions at the time of download.
To Register please email
Shoshana Wodak - shoshana.wodak AT gmail.com, Sameer Velankar - sameer AT ebi.ac.uk, Nurul Nadzirin - nurul AT ebi.ac.uk
Team Leader Name:
Staff Position At your Institute:
If a Team is submitting
For each member please send Name: & email:
Protein-protein interactions and other interactions between macromolecules are essential to all aspects of biology and medical sciences, and a number of methods have been developed to predict them. CAPRI is a community wide experiment designed to assess those that are based on structure. If we know the 3D structure of two components of a complex and build a model of their assembly, how reliable and accurate is that model likely to be?
CAPRI is a blind prediction experiment managed by capri management . Its targets are unpublished crystal or NMR structures of complexes, communicated on a confidential basis by their authors to the CAPRI management. Participant predictor groups are given the atomic coordinates of two proteins that make biologically relevant interactions. They model the target complex with the help of the coordinates and other publicly available data (sequence, mutations etc~), and submit sets of ten models for assessment on the CAPRI Web site. In addition, the predictors are invited to upload larger sets that are communicated to scorer groups who evaluate and rank them, and make a separate ten-model submission. After the prediction round is completed, the CAPRI assessors compare the submissions to the experimental structure, et evaluate the models on criteria that depend on the geometry and biological relevance of the predicted interactions.
Since CAPRI began in 2001, the experiment has had two to four prediction rounds each year, with one or a few targets per round. Each round is announced a week in advance, it lasts 3-6 weeks, and the results are known in the following weeks. To be on the mailing list, please send a message to Sameer Velankar.
Structural biologists and scientists actively engaged in the study macromolecular interactions are invited to participate:
by offering targets -more information
by registering prediction rounds as predictors and/or scorers
Please read and observe the rules of the experiment and the confidentiality agreement that all CAPRI participants must sign.
Information on targets of past CAPRI rounds is available here
Capri Target Publications
CAPRI Special issues and Evaluation Meetings:
- Sixth CAPRI Evaluation Meeting, Tel-Aviv, Israel, April 17-19, 2016
Special issue : Proteins: Structure, Function, and Bioinformatics, Volume 85, Issue 3, 2017.
- Fifth CAPRI Evaluation Meeting, Utrecht, The Netherlands, April 17-19, 2013
Special issue : Proteins: Structure, Function, and Bioinformatics, Volume 81, Issue 12, 2013.
- Fourth CAPRI Evaluation Meeting, Barcelona, Spain, December 9-11, 2009
Special issue : Proteins: Structure, Function, and Bioinformatics, Volume 78, Issue 15, 2010.
- Third CAPRI Evaluation Meeting, Toronto, Canada, April 20–21, 2007
Special issue : Proteins: Structure, Function, and Bioinformatics, Volume 69, Issue 4, 2007.
- Second CAPRI Evaluation Meeting, Gaeta, Italy, December 8-10, 2004.
Special issue : Proteins: Structure, Function, and Bioinformatics, Volume 60, Issue 2, 2005.
- First CAPRI Evaluation Meeting, La Londe des Maures, France, September 19-21, 2002.
Special issue : Proteins: Structure, Function, and Bioinformatics, Volume 52, Issue 1, 2003.
Welcome to CAPRI: A Critical Assessment of PRedicted Interactions Joel Janin, Proteins: Structure, Function, and Genetics Volume 47, Issue 3, 2002. Pages: 257 ( Local Copy: Call For Targets )
Meeting Report. Modeling of protein interactions in genomes Sandor Vajda, Ilya A. Vakser, Michael J.E. Sternberg, Joel Janin, Proteins: Structure, Function, and Genetics Volume 47, Issue 4, 2002. Pages: 444-446 ( Local Copy: Meeting Report )
Assessing predictions of protein-protein interaction: The CAPRI Experiment. J Janin (2005) Protein Sci. 14:278-283.
The Third CAPRI Assessment Meeting, Toronto, Canada, April 20-21, 2007. J. Janin, SJ Wodak (2007) Structure 15, 755-759.
Email Problems or Queries to Sameer Velankar