CAPRI: Critical Assessment of PRediction of Interactions

CAPRI communitywide experiment on the comparative evaluation of protein-protein docking for structure prediction

Hosted by the Protein Data Bank in Europe (PDBe) Group

CAPRI evaluation meeting Tel-Aviv Israel, on April 17-19, 2016

Dear Capriotes and colleagues,

We are pleased to announce that the 6th CAPRI evaluation meeting will take place in Tel-Aviv Israel, on April 17-19, 2016.
Please make sure to mark the date in your calendars!

The meeting is organized by our colleagues, Dr. Haim Wolfson (Tel-Aviv University), Dr. Ora Schueler-Furman (The Hebrew University of Jerusalem), 
and Dr. Gideon Schreiber (the Weizmann Institute of Science), in close collaboration with the CAPRI Management Committee.

The meeting program will include an overview of the performance of protein docking and scoring procedures obtained for targets evaluated since the 
spring of 2013. It will also feature several plenary lectures by prominent scientists, as well as talks by the best CAPRI performers, and/or groups 
developing innovative computational approaches. CAPRI groups selected for oral representations will be notified later in the year, once the predictions 
for all outstanding targets have been completed. 

Details about the venue, the travel arrangements, hotel accommodations and stipends available for students and post-doctoral fellows will be available 
from the Meeting website that will be operational soon.

We hope to see you all in Tel-Aviv next year!

Sameer Velankar and Shoshana Wodak 
The CAPRI Management Committee


ROUND 30 results are now availabe


For more details on registration please see New CAPRI ROUND 34

  • 5th March 2015 - Registration opens for Round 34
  • 16th March 2015 - Round 34 opens - Prediction of targets 104-105 (Both targets represent protein-protein complex)
  • 18th March 2015 - Deadline for server submissions
  • 16th April 2015 - Deadline for submitting predictions
  • 17th April 2015 - Scoring round uploader deadline
  • 21st April 2015 - Scoring round set available
  • 25th April 2015 - Scoring round submission deadline

  • To download the target coordinates you must agree to the following conditions at the time of download.

    Agreement (pdf)

    To Register please email
    Shashana Wodak - shoshana.wodak AT, Sameer Velankar - sameer AT
    Team Leader Name:
    e-Mail Address:
    Staff Position At your Institute:
    If a Team is submitting
    For each member please send Name: & email:

    Protein-protein interactions and other interactions between macromolecules are essential to all aspects of biology and medical sciences, and a number of methods have been developed to predict them. CAPRI is a community wide experiment designed to assess those that are based on structure. If we know the 3D structure of two components of a complex and build a model of their assembly, how reliable and accurate is that model likely to be?

    CAPRI is a blind prediction experiment managed by capri management . Its targets are unpublished crystal or NMR structures of complexes, communicated on a confidential basis by their authors to the CAPRI management. Participant predictor groups are given the atomic coordinates of two proteins that make biologically relevant interactions. They model the target complex with the help of the coordinates and other publicly available data (sequence, mutations etc~), and submit sets of ten models for assessment on the CAPRI Web site. In addition, the predictors are invited to upload larger sets that are communicated to scorer groups who evaluate and rank them, and make a separate ten-model submission. After the prediction round is completed, the CAPRI assessors compare the submissions to the experimental structure, et evaluate the models on criteria that depend on the geometry and biological relevance of the predicted interactions.

    Since CAPRI began in 2001, the experiment has had two to four prediction rounds each year, with one or a few targets per round. Each round is announced a week in advance, it lasts 3-6 weeks, and the results are known in the following weeks. To be on the mailing list, please send a message to Sameer Velankar.

    Structural biologists and scientists actively engaged in the study macromolecular interactions are invited to participate:
    by offering targets -more information
    by registering prediction rounds as predictors and/or scorers

    Please read and observe the rules of the experiment and the confidentiality agreement that all CAPRI participants must sign.

    Information on targets of past CAPRI rounds is available here

    Capri Target Publications

    CAPRI Special issues and Evaluation Meetings:

    Other publications:
    Welcome to CAPRI: A Critical Assessment of PRedicted Interactions Jol Janin, Proteins: Structure, Function, and Genetics Volume 47, Issue 3, 2002. Pages: 257 ( Local Copy: Call For Targets )
    Meeting Report. Modeling of protein interactions in genomes Sandor Vajda, Ilya A. Vakser, Michael J.E. Sternberg, Joel Janin, Proteins: Structure, Function, and Genetics Volume 47, Issue 4, 2002. Pages: 444-446 ( Local Copy: Meeting Report )
    Assessing predictions of protein-protein interaction: The CAPRI Experiment. J Janin (2005) Protein Sci. 14:278-283.
    The Third CAPRI Assessment Meeting, Toronto, Canada, April 20-21, 2007. J. Janin, SJ Wodak (2007) Structure 15, 755-759.

    Email Problems or Queries to Sameer Velankar