Gene Regulation Networks - a Finite State Linear Model

02/03/00

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Table of Contents

Gene Regulation Networks - a Finite State Linear Model 

Gene networks - what does it mean to understand them?

Modelling approach

Simulation and reverse engineering of gene networks

Existing models for gene networks

Boolean network based models

Differential equation based models

Disadvantages of pure models

Hybrid models

Discrete vs. continuous behaviours

A finite state linear model for gene networks - assumptions

Environment:

Substance binding sites

PPT Slide

A gene Gi:

A gene Gi:

A gene Gi:

A gene network

A gene network in action

A gene network in action

A three state binding site

Multistate generalisation

A multistate gene:

PPT Slide

Stochastic generalisation

Concentration change graph

Measurements that we can make (by array experiments)

The reverse engineering problem:

Theorem

Step one:

PPT Slide

Step two

In practice

Reverse engineering in the strict sense

Future work

PPT Slide

Acknoledgements

Author: Alvis Brazma 

Email: brazma@ebi.ac.uk

Home Page: http://www.ebi.ac.uk/~brazma