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EMBO 2007

EMBO Practical Course on Analysis and Informatics of Microarray Data

15-19, October 2007
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

REGISTRATION CLOSED NOW
Deadline for applications: 01/09/2007
Selected candidates will be informed by: 15/09/2007

Organisers

  • Alvis Brazma
    EMBL Outstation – Hinxton, the European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK
  • Wolfgang Huber
    EMBL Outstation – Hinxton, the European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK
  • Misha Kapushesky
    EMBL Outstation – Hinxton, the European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK
  • John Quackenbush
    Department of Biostatistics, 44 Binney Street, Dana-Faber Cancer Institute Smith 822A, Boston, MA 02115, USA
  • Gabriella Rustici
    EMBL Outstation – Hinxton, the European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK

Description

The main objective of the course is to introduce the participants to advanced bioinformatics and statistics methodologies and software tools for analyzing and managing microarray data. The course is aimed at advanced PhD students and post-doctoral researchers who are applying microarray technologies and bioinformatics methods in their research, and who are already familiar with the basic microarray data analysis methods. We expect that the participants will have already performed microarray based experiments, and will bring their own data for analysis during the practical sessions of the course. Bioinformaticians with experience in microarray data handling are also strongly encouraged to participate.

Over the past few years microarrays have become an established technology in molecular biology used in an increasing number of laboratories. An increasing number of data analysis tools are becoming available to researchers of different levels of expertise, and several courses on microarray data analysis are given annually by EMBO and other organizations. Nevertheless, the data analysis are still a major bottleneck in the utilization of these data – the microarray users often find that the naïve analysis methods do not bring the desired results, and at the same time new increasingly sophisticated microarray platforms are introduced, and the new methods are needed to analyze their data. The course will be aimed at familiarizing the participants with such advanced methodologies and teaching to use the advanced tools.

The European Bioinformatics Institute is one of acknowledged leaders in Functional Genomics and data analysis. The co-organizers of the course are internationally acknowledged leaders of the field. The two main motivations for proposing this course are the dissemination of our expertise and acquired knowledge, and filling in the gap in teaching advanced data analysis methods.

References and links

  • http://www.ebi.ac.uk/microarray
  • Bioinformatics and Computational Biology Solutions Using R and Bioconductor Series: Statistics for Biology and Health, Gentleman, R.; Carey, V.; Huber, W.; Irizarry, R.; Dudoit, S. (Eds.), 2005, Hardcover, ISBN: 0-387-25146-4
  • Microarray Gene Expression Data Anlysys – a Beginner’s Guide. Causton H., Quackenbush J., Brazma A., Blackwell Publishing, 2003 (160 pages)

Content

The proposed course will consist of:

  1. Lectures from distinguished speakers;
  2. Presentations from the participants describing their research (in particular microarray based experiments that they have performed or are planning to perform);
  3. Demonstration of DNA-array data analysis software and other relevant bioinformatics resources;
  4. Practical work in using the demonstrated software and resources to analyse either the participants own DNA-array data (preferably) or DNA-array data provided by the organisers;
  5. Final presentations from the participants discussing the data analysis results obtained during the practical session.

It is expected that there will be 7-8 lectures, each around 1 hour long (~15% of the total time of the course). The lectures will give insight into how biological knowledge can be generated from DNA-array experiments and ways of analysing such data. Each participant will be given 15 min for presenting their research (for 30 participants). The software demonstrations will be given at the beginning of practical sessions and may continue during the practical sessions. The practical work will start in the afternoon of the first day and will finish a day before the end of the course, together with demonstrations taking around 50% of the time of the course. The last day will be devoted to the final presentations.

List of speakers

  • Alvis Brazma, EBI
  • Richard Bourgon, EBI
  • Jürg Bähler, Wellcome Trust Sanger Institute
  • Nigel Carter, Wellcome Trust Sanger Institute
  • Anna Farne, EBI
  • Jelle Goeman, Leiden University Medical Center
  • Wolfgang Huber, EBI
  • Misha Kapushesky, EBI
  • Audrey Kauffmann, EBI
  • Patrick Kemmeren, University Medical Center Utrecht
  • Jonh Quackenbush, Dana-Faber Cancer Institute
  • Gabriella Rustici, EBI
  • Denise Scholtens, Northwestern University Medical School
  • Korbinian Strimmer, University of Leipzig

Target Audience

There will be 30 students accepted. This is determined by the size of the IT Training Room in the Conference Centre of the Wellcome Trust Genome Campus. The student selection will be done by the co-organizers of the course in consultations with the EMBO. The student selection criteria will be:

  • relevance of their current work to the objectives of the course
  • scientific excellence of the previous research
  • quality of the applications
  • geographical distribution
  • recommendations from EMBO

Students at early stages of their career will be accepted if the can demonstrate the relevance of their work to the objectives of the course. Students who will have performed DNA-array experiments will be preferred. Ideally the students should have data from their own DNA-array experiments to analyze during the course. Applicants from industry will not be considered (similar courses for industry are given by the EBI separately, without EMBO funding). Staff from the host institutions will not be taken as students, but will be allowed to participate in the lectures. The students from the UK will not be given any preference.

Financial Support

The costs of participant accommodation and catering is paid by EMBO on room sharing basis (two persons per room). The travel costs have to be covered by the participants (financial support may be possible for participants from the Eastern European countries).

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