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A2M Homo sapiens
A2M is differentially expressed in 92 experiments [119 up/115 dn]: 26 organism parts: bone marrow [1 up/2 dn], lung [2 up/1 dn], ...; 30 disease states: normal [7 up/4 dn], breast cancer [0 up/2 dn], ...; 46 cell types, 36 cell lines, 15 compound treatments and 18 other conditions.
Synonyms A2M, CPAMD5, FWP007
Orthologs A2m (Mus musculus)  Mcr (Drosophila melanogaster)  A2MG_RAT (Rattus norvegicus)  (Compare orthologs)
InterPro Term A-macroglobulin complement component, Alpha-2-macroglobulin, N-terminal, Alpha-2-macroglobulin, N-terminal 2, Alpha-macroglobulin, receptor-binding, TonB box, conserved site
Diseases Alzheimer disease, susceptibility to, Emphysema due to alpha-2-macroglobulin deficiency
GO Terms acute-phase response, enzyme binding, extracellular space, interleukin-8 binding, platelet alpha granule lumen
Uniprot P01023  Q9BQ22 
Search EB-eye ENSG00000175899
REST API
Expression Summary
193 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
4
7
Monocyte Cell type
3
2
None Compound treatment
2
3
Stromal cell Cell type
4
Epithelial cell Cell type
3
1
Bone marrow Organism part
2
1
Lung Organism part
1
2
Organism_part Material type
2
Cell Material type
2
PC3 Cell line
2
FLAP Compound treatment
2
HNRPA2B Compound treatment
2
Macrophage Cell type
2
Estrogen receptor 1 negative; ... Test result
2
Cystic change Histology
2
HeLa Cell line
1
1
MK886 Compound treatment
2
Breast cancer Disease state
2
Fibroblast Cell type
1
1
Cervical cancer Disease state
1
1
Primary gastric tumor Organism part
1
SKMEL5 Cell line
1
White blood cells Organism part
1
Caudate nucleus Organism part
1
Cerebellum Organism part
1
Tumor Organism part
1
SW480 Cell line
1
SW620 Cell line
1
MDA468 Cell line
1
MCF7 Cell line
1
Uninfected Infection
1
Ist1 Cell line
1
U87 Cell line
1
U373 Cell line
1
Lipopolysaccharide Compound treatment
1
T-cell lymphoblastic lymphoma Disease state
1
Pretreatment primary sample Clinical info
1
HPL1 Cell line
1
Lymphoid tissue Organism part
1
T47D Cell line
1
Native skin Cell type
1
Benign nevi Disease state
1
HaCaT Cell line
1
Arsenic oxide Compound treatment
1
Grade IV Tumor grading
1
Primary Disease staging
1
Glucocorticoid sensitive Phenotype
1
T-cell acute lymphoblastic leu... Disease state
1
Glioblastoma Disease state
1
Granulocyte Cell type
1
CD34+ Cell type
1
MDA-MB-231 Cell line
1
BT474 Cell line
1
Astrocyte Cell type
1
YCC6 Cell line
1
Epilepsy Disease state
1
R-(-)-apomorphine HCl Compound treatment
1
MCF10A Cell line
1
Smooth muscle Organism part
1
Whole blood Organism part
1
Lymphatic endothelial cell Cell type
1
Lymph node Organism part
1
Tonsil Organism part
1
Johnsen score count 2: Sertoli... Histology
1
Keratinocyte Cell type
1
Erythrocyte Cell type
1
Superficial transitional cell ... Disease state
1
Chondrocyte Cell type
1
Vascular smooth muscle cell Cell type
1
White blood cell Cell type
1
Platelet Cell type
1
Acute promyelocytic leukemia Disease state
1
Gastric cancer Disease state
1
Duchenne muscular dystrophy Disease state
1
Hematopoietic stem cell Cell type
1
Adipose tissue-derived stem ce... Cell type
1
Training set Population
1
Test set Population
1
Glucocorticoid resistant Phenotype
1
ERbeta transfected Genotype
1
Tumor cell Cell type
1
SKBR3 Cell line
1
Macaca mulatta Organism
1
ITV Cell line
1
Kaposi's sarcoma-associated he... Infection
1
Mononuclear cell Cell type
1
Seminiferous tubule Organism part
1
Breast carcinoma Disease state
1
Primary lymphatic endothelial ... Cell type
1
Pancreatic cancer Disease state
1
ITM-E6E7-ST Cell line
1
Rapamycin Compound treatment
1
Differentiated Cell type
1
Naive Cell type
1
Spermatid Cell type
1
Heart Organism part
1
Blood Organism part
1
Atrial mycocardium Organism part
1
Ventricular myocardium Organism part
1
Vasectomized Clinical history
1
T cell Cell type
1
Peripheral blood mononuclear c... Cell type
1
CD16+ dendritic cell Cell type
1
N/a Test result
1
STA ET1 Cell line
1
CD4+ T-cell Cell type
1
Dendritic cell-derived interme... Cell type
1
Not applicable Histology
1
Fu97 Cell line
1
ITM-E6E7 Cell line
1
Invasive ductal carcinoma Histology
1
Obesity Disease state
1
Dendritic cell-derived osteocl... Cell type
1
ERalpha transfected Genotype
1
Pancreas Organism part
1
Conditioned mesenchymal stem c... Cell type
1
ITM-ST Cell line
1
Monocyte-derived osteoclast Cell type
1
ITM Cell line
1
M2 macrophage Cell type
1
Cartilage Organism part
1
Control Phenotype
1
Skeletal muscle Organism part
1
Secretory cell Cell type
1
Monoclonal gammopathy of undet... Disease state
1
Immortalized endothelial cell Cell type
1
Psoriatic lesional biopsy Clinical info
1
Uninvolved biopsy Clinical info
1
CD14+ monocyte Cell type
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
Senescence bypassed Phenotype
1
Testis Organism part
1
Metastatic Disease staging
1
Mercury dichloride Compound treatment
1
Leydig cell Cell type
1
Benign prostatic hyperplasia Disease state
1
Prostate carcinoma Disease state
1
Primary cells Cell line
1
Pancreatic ductal adenocarcino... Disease state
1
Phenol Compound treatment
1
Endothelial cell + pericyte Cell type
1
BDCA3+ dendritic cell Cell type
1
Pan troglodytes Organism
1
Skin substitute Cell type
1
Met5A Cell line
1
GLI60 Cell line
1
0 cm away from the tumor bound... Observation
1
RM 82 Cell line
1
Serum starvation synchronizati... Growth condition
1
Relapse 1; ER status ER+; brai... Clinical info
1
Idiopathic dilated cardiomyopa... Disease state
1
Astrocytoma Disease state
1
Female Sex
1
Male Sex
1
Dimethyl sulfoxide Compound treatment
1
HL-60 Cell line
1
Multiple myeloma Disease state
1
Proliferative Developmental stage
1
Differentiated Developmental stage
1
Pleura Organism part
1
B-precursor acute lymphoblasti... Disease state
1
Neutrophil Cell type
1
Adipocyte Cell type
1
Vulvar intraepithelial neoplas... Disease state
1
Heat-killed HL60 cell lysate Infection
1
BDCA1+ dendritic cell Cell type
1
MKN28 Cell line
1
Chronic pancreatitis Disease state
1
P53 knockdown RNAi
1
SsMCF7 Cell line
1
Germ cell Cell type
1
IL-4 Compound treatment
1
Oligodendroglioma with 1p19q c... Disease state
1
HTERT transduced Gene modification
1
Ethanol Compound treatment
1
Ponasterone A Compound treatment
1
Pergolide methanesulfonate Compound treatment
1
Uterine cervix Organism part
1
Prostate Organism part
1
GLI56 Cell line
1
Bladder mucosa Organism part
1
Bladder Organism part
1
Carcinoma in situ lesion Disease state
1
MKN7 Cell line
1
Malignant pleural mesothelioma Disease state
1
Kaposi's sarcoma Disease state
1
MS428 Cell line
1
Johnsen score count 5: no sper... Histology
1
Chronic myelogenous leukemia Disease state
1
Presymptomatic Disease staging
1
Constipation-predominant Clinical info
1
RD-ES Cell line
1
Expression Profiles
E-GEOD-15460: Transcription profiling of human gastric cancers, cell lines and controls
Experimental Factors
Show expression profile  /  experiment details

 
E-GEOD-5258: Transcription profiling of human cell lines freely cycling treated with 164 distinct small molecules - Broad Connectivity Map CMAP Set 1
Experimental Factors
Show expression profile  /  experiment details

 
E-AFMX-5: Transcription profiling of human cell lines and tissues (GNF/Novartis)
Experimental Factors
Cell type Organism part Disease state
Show expression profile  /  experiment details

 
E-MEXP-1014: Transcription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Experimental Factors
Show expression profile  /  experiment details

 
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