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MAP3K8 Homo sapiens
MAP3K8 is differentially expressed in 108 experiments [105 up/94 dn]: 12 organism parts: kidney [0 up/2 dn], peripheral blood [1 up/1 dn], ...; 23 disease states: normal [4 up/6 dn], acute promyelocytic leukemia [1 up/1 dn], ...; 26 cell types, 28 cell lines, 26 compound treatments and 18 other conditions.
Synonyms COT, ESTF, MAP3K8, RP11-449I17.8-004, RP11-449I17.8-006, RP11-449I17.8-005, RP11-449I17.8-001
Orthologs M3K8_RAT (Rattus norvegicus)  BCK1 (Saccharomyces cerevisiae)  Map3k8 (Mus musculus)  (Compare orthologs)
InterPro Term Mitogen-activated protein kinase kinase kinase 8, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine-protein kinase-like domain, Serine/threonine-protein kinase, active site
Diseases Lung cancer, somatic
GO Terms ATP binding, MAP kinase kinase kinase activity, cell cycle, kinase activity, protein amino acid phosphorylation
Uniprot P41279  Q59FC1  Q5T853  Q5T856  Q6FG25  Q5T857  Q5T854 
Search EB-eye ENSG00000107968
REST API
Expression Summary
167 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
6
4
None Compound treatment
4
3
Stromal cell Cell type
3
MCF-7 Cell line
2
Kidney Organism part
2
BT-474 Cell line
2
Estrogen receptor 1 negative; ... Test result
2
Placebo Compound treatment
1
1
MDA-MB-231 Cell line
2
PC3 Cell line
2
Fibroblast Cell type
1
1
Peripheral blood Organism part
1
1
MK886 Compound treatment
2
HL-60 Cell line
1
1
Cystic change Histology
2
Control Compound treatment
2
Acute promyelocytic leukemia Disease state
1
1
FLAP Compound treatment
2
SW480 Cell line
1
SW620 Cell line
1
Circulating neutrophil Cell type
1
Fetal bovine serum in media Growth condition
1
In vitro neutrophil Cell type
1
Postprandial lipid micelles in... Growth condition
1
ITS medium with albumin-bound ... Growth condition
1
Inter-prandial lipid micelles ... Growth condition
1
ITS medium Growth condition
1
Normal1 Replicate
1
Organism_part Material type
1
Cell Material type
1
Normal5 Replicate
1
HPL1 Cell line
1
Epithelial cell Cell type
1
HeLa Cell line
1
T47D Cell line
1
Mannitol Compound treatment
1
A549 Cell line
1
Lymphatic endothelial cell Cell type
1
Acute lymphocytic leukemia Disease state
1
BJAB Cell line
1
U937 Cell line
1
Glutamine Compound treatment
1
Testicular seminoma Disease state
1
Endothelial cell Cell type
1
Kaposi's sarcoma Disease state
1
Beas2B Cell line
1
Lung Organism part
1
U87 Cell line
1
U373 Cell line
1
5-aza-2'-deoxycytidine Compound treatment
1
Granulocyte macrophage-colony ... Compound treatment
1
Johnsen score count 2: Sertoli... Histology
1
Trichostatin A Compound treatment
1
Platelet-derived growth factor Compound treatment
1
Bladder Organism part
1
Bladder mucosa Organism part
1
MCF10A Cell line
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
Respiratory syncytial virus Infection
1
Metastatic Disease staging
1
Native skin Cell type
1
Lipopolysaccharide Compound treatment
1
Hematopoietic stem cell Cell type
1
Adipose tissue-derived stem ce... Cell type
1
Glucocorticoid resistant Phenotype
1
Vasectomized Clinical history
1
Epidermal keratinocyte Cell type
1
SkinEthic keratinocyte Cell type
1
Synovial fluid Organism part
1
Invasive breast cancer Disease state
1
T2N0M0 Disease staging
1
Superficial transitional cell ... Disease state
1
SsMCF7 Cell line
1
R-(-)-apomorphine HCl Compound treatment
1
Skin substitute Cell type
1
Estrogen receptor 1 positive; ... Test result
1
Lipopolysaccharide and R848 Compound treatment
1
Actinomycin D Compound treatment
1
T3bN1M0 Disease staging
1
SKMEL5 Cell line
1
Total_RNA Material type
1
Polysome-associated RNA Material type
1
Spleen Organism part
1
Trigeminal ganglion Organism part
1
Carcinoma in situ lesion Disease state
1
AZ521 Cell line
1
T47-D Cell line
1
Phenol Compound treatment
1
MDA468 Cell line
1
Jurkat Cell line
1
PT3 Disease staging
1
Huntington's disease Disease state
1
Sapphyrin PCI-2050 Compound treatment
1
KSHV latent infection Disease state
1
Malignant melanoma Disease state
1
No decrease in symptoms Clinical info
1
Keratinocyte Cell type
1
Immediately after exercise Clinical info
1
Ultraviolet light Light
1
Sapphyrin PCI-2051 Compound treatment
1
BT474 Cell line
1
CD8+ naive CD8 T cell Cell type
1
Invasive ductal carcinoma Histology
1
Monocyte at intermediate diffe... Cell type
1
Pancreatic cancer Disease state
1
Crohn's disease Disease state
1
Chronic lymphocytic leukemia Disease state
1
White blood cell Cell type
1
Platelet Cell type
1
Staphylococcus aureus Infection
1
Normal Disease staging
1
Uninfected Infection
1
Pan troglodytes Organism
1
Pretreatment primary sample Clinical info
1
Multiple myeloma Disease state
1
Bacterial endotoxin Compound treatment
1
PT2 Disease staging
1
Monocyte Cell type
1
Lin- CD34- Phenotype
1
IgV status unknown Genotype
1
M-CSF Compound treatment
1
Ethanol Compound treatment
1
Ponasterone A Compound treatment
1
Benign Disease staging
1
Unknown_sex Sex
1
PCep4 control vector transfect... Gene modification
1
ETat plasmid transfection Gene modification
1
Macaca mulatta Organism
1
Benign prostatic hyperplasia Disease state
1
Prostate carcinoma Disease state
1
Primary cells Cell line
1
Obesity Disease state
1
Pancreatic ductal adenocarcino... Disease state
1
Monoclonal gammopathy of undet... Disease state
1
PT1 Disease staging
1
Teratozoospermia Disease state
1
Normospermic Disease state
1
Skeletal muscle Organism part
1
TIVE Cell line
1
17beta-estradiol Compound treatment
1
Control RNAi
1
SIM2s RNAi
1
Grade IV Tumor grading
1
CD4+ T cell Cell type
1
CD8+ T cell Cell type
1
Atrioventricular node Organism part
1
T3aNxMx Disease staging
1
Baseline propofol Compound treatment
1
Heregulin Compound treatment
1
KSHV-negative EBV-positive Clinical info
1
IBL4 Cell line
1
Geriatric Developmental stage
1
Pediatric Developmental stage
1
Cerebellum Organism part
1
Lung adenocarcinoma Disease state
1
BDCA1+ dendritic cell Cell type
1
T4aNxMx Disease staging
1
TMK1 Cell line
1
Sevoflurane Compound treatment
1
Seminiferous tubule Organism part
1
IgV unmutated Genotype
1
Infrared light Light
1
Kaposi's sarcoma-associated he... Infection
1
Primary fibroblast Cell type
1
CD14+ monocyte Cell type
1
PDGF-A dominant-negative Genotype
1
Expression Profiles
E-MEXP-1014: Transcription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Experimental Factors
Show expression profile  /  experiment details

 
E-GEOD-2322: Transcription profiling of human neutrophils obtained after exposure endotoxin by bronchoscopic instillation reveals differential gene expression between air space and circulating neutrophils
Experimental Factors
Show expression profile  /  experiment details

 
E-MEXP-1446: Transcription profiling of human enterocytes cultured with different dietary lipids
Experimental Factors
Growth condition
Show expression profile  /  experiment details

 
E-GEOD-5823: RNAi profiling of human cancer cell lines depleted for c-MYC depletion
Experimental Factors
Disease state RNAi Cell line
Show expression profile  /  experiment details

 
E-GEOD-1563: Transcription profiling of human kidney and peripheral blood lymphocytes from kidney transplant patients
Experimental Factors
Clinical info Organism part
Show expression profile  /  experiment details

 
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