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IKBKB Homo sapiens
IKBKB is differentially expressed in 117 experiments [127 up/134 dn]: 34 organism parts: bone marrow [0 up/2 dn], skeletal muscle [1 up/1 dn], ...; 42 disease states: normal [7 up/9 dn], glioblastoma [2 up/0 dn], ...; 30 cell types, 21 cell lines, 20 compound treatments and 19 other conditions.
Synonyms IKBKB, IKKB
Orthologs Ikbkb (Mus musculus)  ird5 (Drosophila melanogaster)  Y39G8B.5 (Caenorhabditis elegans)  ikke-1 (Caenorhabditis elegans)  IKKB_RAT (Rattus norvegicus)  (Compare orthologs)
InterPro Term Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine-protein kinase, active site, Ubiquitin supergroup, Serine/threonine-protein kinase-like domain
GO Terms ATP binding, IkappaB kinase activity, anti-apoptosis, identical protein binding, protein amino acid phosphorylation
Uniprot O14920  Q59GL9 
Search EB-eye ENSG00000104365
REST API
Expression Summary
215 factor values, click each to filter
Factor Value Factor Up/Down
Legend: - number of studies the gene is up/down in
Normal Disease state
9
7
Stromal cell Cell type
2
2
Epithelial cell Cell type
3
1
None Compound treatment
2
1
Control Compound treatment
2
Glioblastoma Disease state
2
FLAP Compound treatment
2
MK886 Compound treatment
2
Breast carcinoma Disease state
2
MCF-7 Cell line
2
HL-60 Cell line
2
Not applicable Histology
2
Endothelial cell Cell type
2
N/a Test result
2
HNRPA2B Compound treatment
2
0 cm away from the tumor bound... Observation
2
MDA-MB-231 Cell line
1
1
Invasive ductal carcinoma Histology
2
PC3 Cell line
2
Homo sapiens Organism
2
Acute promyelocytic leukemia Disease state
2
Bone marrow Organism part
2
Organism_part Material type
1
1
Cell Material type
1
1
HeLa Cell line
1
1
BT-474 Cell line
1
1
Skeletal muscle Organism part
1
1
Cerebellum Organism part
1
Frontal cortex, primary motor ... Organism part
1
Plasma cell Cell type
1
B lymphocyte Cell type
1
Glucocorticoid sensitive Phenotype
1
Epilepsy Disease state
1
Pretreatment primary sample Clinical info
1
Grade IV Tumor grading
1
Lymphatic endothelial cell Cell type
1
Bacterial endotoxin Compound treatment
1
Baseline uninfected Disease state
1
Frontal cortex, superior motor... Organism part
1
Ultraviolet light Light
1
Tumor Organism part
1
Glucocorticoid resistant Phenotype
1
Methotrexate Compound treatment
1
Multiple myeloma Disease state
1
T47-D Cell line
1
Chronic lymphocytic leukemia Disease state
1
SKBR3 Cell line
1
Stage II Disease staging
1
Fibroblast Cell type
1
MCF7 Cell line
1
Johnsen score count 2: Sertoli... Histology
1
R-(-)-apomorphine HCl Compound treatment
1
Fetal bovine serum in media Growth condition
1
T47D Cell line
1
Rapamycin Compound treatment
1
Superficial transitional cell ... Disease state
1
Malignant melanoma Disease state
1
Benign prostatic hyperplasia Disease state
1
Prostate carcinoma Disease state
1
Primary cells Cell line
1
Atrial mycocardium Organism part
1
Ventricular myocardium Organism part
1
CodeLink Labeling Protocol type
1
HaCaT Cell line
1
Relapse 1; ER status ER+; brai... Clinical info
1
Uninfected Infection
1
Native skin Cell type
1
None Light
1
Epidermal keratinocyte Cell type
1
SkinEthic keratinocyte Cell type
1
Johnsen score count 5: no sper... Histology
1
Testis Organism part
1
Stage I Disease staging
1
Macaca mulatta Organism
1
Geriatric Developmental stage
1
Pediatric Developmental stage
1
Astrocytoma Disease state
1
White blood cell Cell type
1
Platelet Cell type
1
Alveolar space neutrophil Cell type
1
Lipopolysaccharide Compound treatment
1
Cigarette smoke Growth condition
1
Incubator control Growth condition
1
Serum starvation + thymidine b... Growth condition
1
HPL1 Cell line
1
Vascular smooth muscle cell Cell type
1
Superficial transitional cell ... Disease state
1
Primary Disease staging
1
Kaposi's sarcoma-associated he... Infection
1
Chondrocyte Cell type
1
Johnsen score count 3.2: Serto... Histology
1
T4aN0M0 Disease staging
1
Acute malaria, natural infecti... Disease state
1
Vanadium pentoxide Compound treatment
1
Circulating neutrophil Cell type
1
Lung Organism part
1
Johnsen score count 10: full s... Histology
1
Smooth muscle Organism part
1
Superior cervical ganglion Organism part
1
Heart Organism part
1
Spermatid Cell type
1
BT474 Cell line
1
U937 Cell line
1
Testis - seminiferous tubule Organism part
1
MDA468 Cell line
1
Fisetin Compound treatment
1
Ischemic cardiomyopathy Disease state
1
X-linked chronic granulomatous Disease state
1
Primary gastric tumor Organism part
1
Trichostatin A Compound treatment
1
Estrogen receptor 1 positive; ... Test result
1
Astrocytic tumor Disease state
1
Grade III Tumor grading
1
Benign nevi Disease state
1
Cartilage Organism part
1
Cigarette smoke Compound treatment
1
Duchenne muscular dystrophy Disease state
1
Thalamus Organism part
1
T1bN0M0 Disease staging
1
AdERb high moi Gene modification
1
Hematopoietic stem cell Cell type
1
Adipose tissue-derived stem ce... Cell type
1
Dimethyl sulfoxide Compound treatment
1
ITS medium with albumin-bound ... Growth condition
1
Postprandial lipid micelles in... Growth condition
1
Relapse 0; ER status ER+; brai... Clinical info
1
Ciliary ganglion Organism part
1
Umbilical cord Organism part
1
Adult Developmental stage
1
Infant Developmental stage
1
Trigeminal ganglion Organism part
1
Seminiferous tubule Organism part
1
ITS medium Growth condition
1
ERalpha transfected Genotype
1
ERbeta transfected Genotype
1
T-cell lymphoblastic lymphoma Disease state
1
Bronchial epithelial cell Cell type
1
Control - untreated Compound treatment
1
B-precursor acute lymphoblasti... Disease state
1
Keratinocyte Cell type
1
Kaposi's sarcoma Disease state
1
SM1 Cell line
1
Lymphoid tissue Organism part
1
Inter-prandial lipid micelles ... Growth condition
1
Carcinoma in situ lesion Disease state
1
SCH Cell line
1
Experimental malaria-infected Disease state
1
Astrocyte Cell type
1
Enzo Labeling Protocol type
1
White blood cells Organism part
1
Non-ischemic cardiomyopathy Disease state
1
None Gene modification
1
Training set Population
1
Test set Population
1
Thymus Organism part
1
Psoriatic lesional biopsy Clinical info
1
Uninvolved biopsy Clinical info
1
Affymetrix Labeling Protocol type
1
Wilms' tumor Disease state
1
Dorsal root ganglion Organism part
1
Monoclonal gammopathy of undet... Disease state
1
Globus pallidus Organism part
1
Neutrophil Cell type
1
5-aza-2'-deoxycytidine Compound treatment
1
Floor of mouth/tonsil Organism part
1
Lymph node Organism part
1
Tonsil Organism part
1
CD3+ CD4+ CD8- CD45RA+ CD62L+ Phenotype
1
Naive T cell Cell type
1
A. fumigatus condia in media Growth condition
1
Atrioventricular node Organism part
1
Anaplastic oligodendroglioma Disease state
1
MDS-associated acute myeloid l... Disease state
1
Acute myeloid leukemia Disease state
1
CXCR5(-)ICOS(-/lo) CD4 T cell Target cell type
1
Gastric cancer Disease state
1
CD34+ Cell type
1
Essential thrombocythemia Disease state
1
Childhood acute myeloid leukem... Disease state
1
SKMEL5 Cell line
1
CD16+ dendritic cell Cell type
1
Cystic change Histology
1
Crohn's disease Disease state
1
CD4+ T cell Cell type
1
Spermatocyte Cell type
1
Uterus corpus Organism part
1
KSHV-negative EBV-positive Clinical info
1
ITM Cell line
1
Dermatomyositis Disease state
1
Plasma cell leukemia Disease state
1
CD3int CD4+ CD8+ Phenotype
1
Double positive thymocyte Cell type
1
Smoker Clinical info
1
Non-smoker Clinical info
1
T4bN1M0 Disease staging
1
Plasmacytoid dendritic cell Cell type
1
Temporal lobe Organism part
1
Down syndrome Disease state
1
T4aN2Mx Disease staging
1
Liver Organism part
1
Placebo Compound treatment
1
Glutamine Compound treatment
1
Polycystic ovary syndrome Disease state
1
Actinomycin D Compound treatment
1
YCC1 Cell line
1
Pancreatic cancer Disease state
1
Pseudomonas aeruginosa Infection
1
Wild_type Genotype
1
PML/RAR Genotype
1
Breast cancer Disease state
1
Cervical cancer Disease state
1
Control RNAi
1
SIM2s RNAi
1
Gorilla gorilla Organism
1
Appendix Organism part
1
Expression Profiles
E-GEOD-6691: Transcription profiling of human blood and bone marrow samples from patients with Waldenstron's macroglobulinemia, chronic lymphocytic leukemia (CLL), multiple myeloma and normal individuals to indentify genes with functions in B-cell differentiation and oncogenesis
Experimental Factors
Disease state Cell type
Show expression profile  /  experiment details

 
E-GEOD-4646: Transcription profiling of human HUVEC cells infected with Neisseria meningitidis wild type and mutants vs uninfected sampled at 3 time points
Experimental Factors
Time Infection
Show expression profile  /  experiment details

 
E-GEOD-5824: Transcription profiling of human Acute Lymphoblastic Leukemia CEM_C1 cells treated with rapamycin identifies rapamycin as a glucocorticoid resistance reversal agent
Experimental Factors
Show expression profile  /  experiment details

 
E-GEOD-4290: Transcription profiling of human glioma tumor samples
Experimental Factors
Disease state Tumor grading
Show expression profile  /  experiment details

 
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