I completed my PhD with Professor Janet
Thornton at University College London (1996-2000), studying the basis
for specificity of DNA-binding proteins. I then moved to Yale University
as a post-doctoral fellow with Professor Mark Gerstein (2000-2004).
During this time, I shifted my research focus to genomics, with a
particular emphasis on yeast transcription regulation. I have been a
Group Leader at EMBL-EBI since 2005. This photo was taken in Peru - it
reminds me of the wonderful break I had travelling in South America after
finishing my
post-doc!
I am a PhD student in Nick Luscombe's group. I obtained a bachelor's degree
in Molecular Biology and Genetics in 2007 and a master's degree in
Biomedical Informatics in 2009, both in the University of Lisbon, Portugal.
I started my PhD at EBI in October 2009. My interests lie in global
principles of gene regulation in higher eukaryotes. At the moment my work
focuses on gene regulation by chromatin modifications.
I did my PhD in Thomas Jenuwein’s laboratory at the IMP in Vienna.
I’m interested in transcriptional gene regulation by epigenetic mechanisms.
During my PhD I characterised a histone methyltransferase knock-out mouse embryonic stem cell line.
I mapped several histone methylation marks in wild type and knock-out cells, and related the changes
in the histone methylation profiles to impaired stem cell potential in differentiation and reprogramming assays.
In Nick Luscombe’s group my aim is to investigate to what extent do pathogen-expressed histone modifying
enzymes play a role in modulating the host’s response during infection.
I am a PhD student in Nick Luscombe's group. In 2007 I graduated in Biology
and Biochemistry at University of Navarra (Spain). In 2008 I moved to the
EBI, first as a Marie Curie visiting student and then as a PhD student. My
interests extend to a wide range of fields in theoretical and evolutionary
biology. The focus of my PhD is using phylogenetics, population genetics
and new sequencing technologies to study the origin and control of
mutations in bacteria and cancer.
My area of focus is bacterial genomics. In bacterial genomics, I am
interested in: (i)The rules that govern genome design and architecture. I
study this at the level of base composition of the genome, as well as at
the level of synteny of conserved genes across several genera. (ii)
Transcriptional regulation of pathogenesis in enterobacteria. Currently,
in collaboration with Gordon Dougan’s lab in Sanger Centre, we are tagging
transcription factors involved in pathogenesis of Salmonella typhimurium.
We will experimentally determine the regulatory network in this organism. I
intend to extend this work to various other pathogens, creating a platform
for comparative study. (iii) Variation in orthologous transcriptional networks in related species of pathogens
I obtained my Master's degree in computer science from the Budapest
University of Technology and Economics in 2000 with the research focus on
mobile agents. After that I worked for Nokia Networks (Budapest, 2000-2004)
developing 3G wireless networks and later at Microsoft Research (Aachen,
2004-2010) working on pedestrian navigation, sensor networks, robotics and
cloud computing. I was fascinated with biology ever since the Human Genome
Project was completed and started taking courses at the MIT OpenCourseWare
(2007-2010). I also started my pet research project: GenDiff, a
differential compression tool for genetic data.
My current research focus is the three dimensional structure of the
eukaryotic nucleus and its connection to biological function. This
computational work centres around analysing data from Hi-C assays. I
am also interested in bacterial genomics, synthetic biology and molecular
computation.
I work on investigating the transcriptional
regulatory systems of high
eukaryote organisms, with a particular focus on human and fly. During
my PhD at the CNIO
and Universidad
Autónoma de Madrid, Spain, to further our
understanding of the repertoire of human transcriptional activators
and repressors, I completed the identification and functional
classification of 1,369 sequence-specific DNA-binding proteins in the
human genome. Further studies with these regulatory proteins will lend
insight into the basic principles that govern tissue-specific and
condition-specific transcriptional activity in higher eukaryotes.
Recent parallel work in fly, in collaboration with the Akhtar lab at
EMBL, allowed us
to identify the histone acetyltransferase MOF as a global regulator of
gene expression, besides its function in controlling dosage
compensation.
I am a post-doc in Nick Luscombe's
group. I did my PhD with Michael
Feldbrügge at the MPI for Terrestrial Microbiology in Marburg,
Germany, working on signal transduction and post-translational
regulation of transcription in a fungal pathogen. Switching from
experimental biology to bioinformatics, I joined the group of Nick
Luscombe in summer 2009 to study the complex network of
post-transcriptional regulation in humans. My aim is to identify and
characterise RNA-binding proteins that constitute key players at
different steps of mRNA regulation. In particular, I am interested in
the combinatorial regulation of IRES-mediated translation in
collaboration with the group of Matthias Hentze at EMBL.
I'm a PhD student in Nick
Luscombe's group since Oct. 2007. My degree in Chemical Biology I
obtained at ETH Zurich in Switzerland. I wrote my Diploma Thesis at the
Institute of Systems Biology at ETH with Matthias Heinemann (http://www.imsb.ethz.ch/)
where I worked on modeling the regulation of E.coli's central carbon
metabolism. My current interest is the understanding of dynamics in gene
regulation and underlying mechanisms in model organisms. In particular I
study changes in gene expression patterns in yeast and E.coli in order
to understand underlying transcriptional regluation mechanisms.
