spacer

Luscombe Group Members

 






Nick Luscombe

Nick Luscombe, Group Leader

I completed my PhD with Professor Janet Thornton at University College London (1996-2000), studying the basis for specificity of DNA-binding proteins. I then moved to Yale University as a post-doctoral fellow with Professor Mark Gerstein (2000-2004). During this time, I shifted my research focus to genomics, with a particular emphasis on yeast transcription regulation. I have been a Group Leader at EMBL-EBI since 2005. This photo was taken in Peru - it reminds me of the wonderful break I had travelling in South America after finishing my post-doc!

Home | Contact
 
Sydney Brenner

Sydney Brenner, Visitor



Contact
 
Filipe Cadete

Filipe Cadete, PhD Student

I am a PhD student in Nick Luscombe's group. I obtained a bachelor's degree in Molecular Biology and Genetics in 2007 and a master's degree in Biomedical Informatics in 2009, both in the University of Lisbon, Portugal. I started my PhD at EBI in October 2009. My interests lie in global principles of gene regulation in higher eukaryotes. At the moment my work focuses on gene regulation by chromatin modifications.

Contact
 
Maria Dermit

Maria Dermit


Contact
 
Borbala Gerle

Borbala Gerle, Visitor

I did my PhD in Thomas Jenuwein’s laboratory at the IMP in Vienna. I’m interested in transcriptional gene regulation by epigenetic mechanisms. During my PhD I characterised a histone methyltransferase knock-out mouse embryonic stem cell line. I mapped several histone methylation marks in wild type and knock-out cells, and related the changes in the histone methylation profiles to impaired stem cell potential in differentiation and reprogramming assays. In Nick Luscombe’s group my aim is to investigate to what extent do pathogen-expressed histone modifying enzymes play a role in modulating the host’s response during infection.

Contact
 
Vladimir Kiselev

Vladimir Kiselev


Contact
 
Inigo Martincorena

Inigo Martincorena, PhD Student

I am a PhD student in Nick Luscombe's group. In 2007 I graduated in Biology and Biochemistry at University of Navarra (Spain). In 2008 I moved to the EBI, first as a Marie Curie visiting student and then as a PhD student. My interests extend to a wide range of fields in theoretical and evolutionary biology. The focus of my PhD is using phylogenetics, population genetics and new sequencing technologies to study the origin and control of mutations in bacteria and cancer.

Contact
Ana Isabel Prieto

Ana Isabel Prieto, Postdoctoral Fellow



Contact
Karthikeyan Sivaraman

Karthikeyan Sivaraman, ESPOD Fellow

My area of focus is bacterial genomics. In bacterial genomics, I am interested in: (i)The rules that govern genome design and architecture. I study this at the level of base composition of the genome, as well as at the level of synteny of conserved genes across several genera. (ii) Transcriptional regulation of pathogenesis in enterobacteria. Currently, in collaboration with Gordon Dougan’s lab in Sanger Centre, we are tagging transcription factors involved in pathogenesis of Salmonella typhimurium. We will experimentally determine the regulatory network in this organism. I intend to extend this work to various other pathogens, creating a platform for comparative study. (iii) Variation in orthologous transcriptional networks in related species of pathogens

Contact
 
Robert Sugar

Robert Sugar, Ph.D Student

I obtained my Master's degree in computer science from the Budapest University of Technology and Economics in 2000 with the research focus on mobile agents. After that I worked for Nokia Networks (Budapest, 2000-2004) developing 3G wireless networks and later at Microsoft Research (Aachen, 2004-2010) working on pedestrian navigation, sensor networks, robotics and cloud computing. I was fascinated with biology ever since the Human Genome Project was completed and started taking courses at the MIT OpenCourseWare (2007-2010). I also started my pet research project: GenDiff, a differential compression tool for genetic data. My current research focus is the three dimensional structure of the eukaryotic nucleus and its connection to biological function. This computational work centres around analysing data from Hi-C assays. I am also interested in bacterial genomics, synthetic biology and molecular computation.

Contact
Juanma Vaquerizas

Juanma Vaquerizas, Staff Scientist

I work on investigating the transcriptional regulatory systems of high eukaryote organisms, with a particular focus on human and fly. During my PhD at the CNIO and Universidad Autónoma de Madrid, Spain, to further our understanding of the repertoire of human transcriptional activators and repressors, I completed the identification and functional classification of 1,369 sequence-specific DNA-binding proteins in the human genome. Further studies with these regulatory proteins will lend insight into the basic principles that govern tissue-specific and condition-specific transcriptional activity in higher eukaryotes. Recent parallel work in fly, in collaboration with the Akhtar lab at EMBL, allowed us to identify the histone acetyltransferase MOF as a global regulator of gene expression, besides its function in controlling dosage compensation.

Contact
 
Alessandra
Vigilante Alessandra Vigilante, Visitor

Contact
 
Katharina Zarnack

Katharina Zarnack, Postdoctoral Fellow

I am a post-doc in Nick Luscombe's group. I did my PhD with Michael Feldbrügge at the MPI for Terrestrial Microbiology in Marburg, Germany, working on signal transduction and post-translational regulation of transcription in a fungal pathogen. Switching from experimental biology to bioinformatics, I joined the group of Nick Luscombe in summer 2009 to study the complex network of post-transcriptional regulation in humans. My aim is to identify and characterise RNA-binding proteins that constitute key players at different steps of mRNA regulation. In particular, I am interested in the combinatorial regulation of IRES-mediated translation in collaboration with the group of Matthias Hentze at EMBL.

Contact
 
Judith Zaugg

Judith Zaugg, PhD Student

I'm a PhD student in Nick Luscombe's group since Oct. 2007. My degree in Chemical Biology I obtained at ETH Zurich in Switzerland. I wrote my Diploma Thesis at the Institute of Systems Biology at ETH with Matthias Heinemann (http://www.imsb.ethz.ch/) where I worked on modeling the regulation of E.coli's central carbon metabolism. My current interest is the understanding of dynamics in gene regulation and underlying mechanisms in model organisms. In particular I study changes in gene expression patterns in yeast and E.coli in order to understand underlying transcriptional regluation mechanisms.

Contact
 






























spacer
spacer