IPD - MHC Database

Welcome to the IPD - MHC Database

The IPD - MHC Database provides a centralised repository for sequences of the Major Histocompatibility Complex (MHC) from a number of different species. Through a number of international collaborations IPD is able to provide the MHC sequences of different species. The sequences provided by each group are curated by experts in the field and then submitted to the central database.

Nomenclature for MHC genes and alleles in species other than humans and mice has historically been overseen either informally by groups generating sequences, or by formal nomenclature committees set up by the International Society for Animal Genetics (ISAG). This work is now overseen by the Comparative MHC Nomenclature Committee and is supported by ISAG and the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS).

• Ellis SA, Bontrop RE, Antczak DF, Ballingall K, Davies CJ, Kaufman J, Kennedy LJ, Robinson J, Smith DM, Stear MJ, Stet RJM, Waller MJ, Walter L and Marsh SGE
  ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005
  Immunogenetics (2006), 57: 953–958
  

IPD - MHC Groups

The following groups have provided data. The individual group pages provide further data on the species included, nomenclature and access to the sequences.

	Canines (DLA) Domestic Dogs, Wolves, Coyotes Lorna Kennedy		Non-Human Primates (NHP) Apes, Old and New World Monkeys Ronald Bontrop / Natasja de Groot
	Cattle Cattle, Buffalo and Bison Shirley Ellis		Rats (RT1) Rat Lutz Walter
	Felines (FLA) Domestic Cats Lorna Kennedy		Sheep (OLA) Sheep Keith Ballingall / Mike Stear
	Fish Atlantic salmon, rainbow trout René Stet		Swine (SLA) Pigs Douglas Smith

The following sections are also under development.

Chickens (B & Y) Chickens Jim Kaufmann

Pinnipeds Seals and Sea Lions John Hammond

Horses (ELA) Horses Doug Antczak

Prosimians Ring Tailed Lemurs Leslie Knapp

Official Species Designations

Full details of all the species included in IPD - MHC and their official designations are available here. If you are working on MHC nomenclature and your species is not represented above please complete the following form, which will submit a request for a new 4 letter code to the Comparitive MHC Nomenclature Committee. Nomenclature committees representing different species or groups should also contact IPD Support for further information about the inclusion of their sequences into the IPD - MHC Database.

Developers

Development of the IPD - MHC database has been undertaken by the following individuals.

• Anthony Nolan Research Institute
  • Steven GE Marsh
  • James Robinson

• European Bioinformatics Institute
  • Peter Stoehr

Further Information

For information regarding IPD please contact IPD Support.