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IPD-KIR DatabaseDonor KIR B-content group calculatorKiller-cell Immunoglobulin-like Receptor (KIR) genes form a diverse, immunogenetic system unlinked to HLA. Group A and B KIR haplotypes have distinctive centromeric (Cen) and telomeric (Tel) gene-content motifs. With the goal of developing a donor selection strategy to improve transplant outcome, Cooley et al., compared the contribution of these motifs to the clinical benefit conferred by B haplotype donors. Donor KIR genotype influenced transplantation outcome for AML, but not ALL, after HLA-matched or mismatched T-cell replete unrelated donor transplants. Compared to A haplotype motifs, centromeric and telomeric B motifs both contributed to relapse protection and improved survival, but Cen-B homozygosity had the strongest independent effect. KIR genotyping several best HLA-matched potential donors should substantially increase the frequency of transplants using unrelated donor grafts with favorable KIR gene content. Adopting this practice could result in superior disease-free survival for patients transplanted for AML. This calculator allows you to enter the genotypes for up to five prospective donors, and receive their assignments to one of 3 groups based on KIR B-content. The groups, "Neutral", "Better", "Best", refer to the associated relapse protection seen in T-cell replete URD HCT for AML. Simply enter the prospective donor's KIR genotype by selecting the appropriate box for each gene. A tick indicates presence of a gene in the donor's genotype. All genotypes are compared to a list of predicted genotypes. These genotypes are generated based on known KIR haplotypes and has been supplemented with a number of additional KIR genotypes that have been defined in routine KIR typing. Currently over 180 KIR genotypes are included. If a Prospective Donor's KIR Typing does not match any of the genotypes on this list a warning is issued. Further InformationFor more information about the database, queries (including website) please contact IPD Support. Please see our licence for terms of use.
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Disclaimer - This research tool is being offered as a tool to predict donor KIR B-content groups assignments as reported in:
S Cooley, DJ Weisdorf, LA Guethlein, JP Klein, T Wang, CT Le, SGE Marsh, D Geraghty, S Spellman, MD Haagenson, M Ladner, E Trachtenberg, P Parham and JS Miller.
Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia.
Blood (2010) 116:2411-9.
No information inputted into this tool is collected or stored on our servers.