Release 2.5.0, 11 October 2013
The database provides a centralised repository for human KIR sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic and haplotypic level. KIRs are members of the immunoglobulin superfamily (IgSF) formerly called Killer-cell Inhibitory Receptors. They are composed of two or three Ig-domains, a transmembrane region and cytoplasmic tail which can in turn be short (activatory) or long (inhibitory). The Leukocyte Receptor Complex (LRC) which encodes KIR genes has been shown to be polymorphic, polygenic and complex like the MHC.
This work was supported by National Institutes of Health Grant P01-CA-111412.
Development of the KIR Database has been undertaken by the following individuals and funded by an NIH P01 grant, P01CA111412.
Nolan Research Institute
University Medical School
||University of Minnesota