The database provides a centralised repository for the data which define the human platelet antigens (HPA). Alloantibodies against human platelet antigens are involved in neonatal alloimmune thrombocytopenia, post-transfusion purpura and refractoriness to random donor platelets . The Human Platelet Antigen (HPA) nomenclature system was adopted in 1990 to overcome problems with the previous nomenclature. Since then more antigens have been described and meanwhile the molecular basis of many has been resolved, and the nomenclature was revised in 2003.
Development of the HPA Database has been undertaken by the following individuals.
Institute of Biological Standards and Control
- Paul Metcalfe
- University of Cambridge
- Nick Watkins
Nolan Research Institute
- James Robinson
- Steven GE Marsh
Search the HPA Database
For allele designation and sequence information select a protein from the first drop-down menu and then select either nucleotide or amino acid from the second drop-down menu. When you have made your selection press the "Go" button.
Where discrepancies have arisen between reported sequences and those stored in the database, the original authors have been contacted where possible, and necessary amendments to published sequences have been incorporated in to this alignment. Future sequencing may identify errors in this list and we would welcome any evidence that helps to maintain the accuracy of these sequence alignments.
If you are interested in submitting sequences to the database please contact Nick Watkins firstname.lastname@example.org for further information.