InterPro results for type:domain

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SH2D1A, SH2 domain (IPR035876) SH2 domain-containing protein 1A (SH2D1A) is an adaptor protein that appears to regulate B-cell differentiation via switching of SLAM (CD150)-mediated signalling pathways. The SLA...

SMOC-2, extracellular calcium-binding domain (IPR037640) SMOC-2 is a ubiquitously expressed matricellular protein that enhances the response to angiogenic growth factors, mediate cell adhesion, keratinocyte migration, and metastasis. It...

VAV3, SH2 domain (IPR035881) The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 ar...

Nck1, SH2 domain (IPR035882) Cytoplasmic proteins Nck are non-enzymatic adaptor proteins composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain. They regulate actin cytoskeleton dynamics b...

Nck2, SH2 domain (IPR035883) Cytoplasmic proteins Nck are non-enzymatic adaptor proteins composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain. They regulate actin cytoskeleton dynamics b...

SH2D2A, SH2 domain (IPR035884) In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing pr...

SH2D7, SH2 domain (IPR035885) In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing pr...

STAT5b, SH2 domain (IPR035886) STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) ar...

CIS, SH2 domain (IPR035887) Cytokine-inducible SH2-containing protein (CIS) is a member of the suppressor of cytokine signaling (SOCS) family proteins. CIS is involved in the negative regulation of cytokines...

Myotubularin-related protein 3, PH-GRAM domain (IPR035888) MTMR3 is a member of the myotubularin dual specificity protein phosphatase gene family. MTMR3 binds to phosphoinositide lipids through its PH-GRAM domain, and can hydrolyze phosph...