InterPro results for type:active_site

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Peptidase S8, subtilisin, His-active site (IPR022398) This entry represents the conserved sequence around the His active site.Subtilases are an extensive family of serine proteases belonging to the MEROPS peptidase family S8 (subtili...

Pyridine nucleotide-disulphide oxidoreductase, class-II, active site (IPR008255) The pyridine nucleotide-disulphide reductases (PNDR) use the isoalloxazine ring of FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a re...

Lipase, GDSL, active site (IPR008265) A variety of lipolytic enzymes with serine as part of the active site have been identified. Protein sequences which contain this active site signature include; Aeromonas hydrophil...

Malate dehydrogenase, active site (IPR001252) Malate dehydrogenase (MDH) catalyzes the interconversion of malate to oxaloacetate utilizing the NAD/NADH cofactor system. The enzyme participates in the citric acid cycle and exi...

Pyroglutamyl peptidase I, Cys active site (IPR033694) Pyroglutamyl peptidase I (also known as PGP-1, pyrrolidone-carboxylate peptidase, PYRase) is the enzyme that selectively removes pyroglutamate (pGlu) from the N terminus of protei...

DNA topoisomerase, type IA, active site (IPR023406) DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand...

Peptidase family C14A, cysteine active site (IPR033139) Interleukin-1 beta converting enzyme (ICE) is responsible for the cleavage of the IL-1 beta precursor at an Asp-Ala bond to generate the mature biologically active cytokine. ICE a...

Phosphoenolpyruvate carboxylase, Lys active site (IPR018129) Phosphoenolpyruvate carboxylase (PEPcase) catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate by bicarbonate to yield oxaloacetate and phosphate. The enzyme is fo...

Cysteine peptidase, asparagine active site (IPR025661) Thiol (cysteine) proteases (EC 3.4.22.-) are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is faci...

Galactose-1-phosphate uridyl transferase, class I His-active site (IPR019779) Galactose-1-phosphate uridyl transferase (galT) catalyses the transfer of an uridyldiphosphate group on galactose (or glucose) 1-phosphate. During the reaction, the uridyl moiety...