InterPro

Small GTPase superfamily, Ras type (IPR020849) Ras proteins are small GTPases that regulate cell growth, proliferation and differentiation. The different Ras isoforms: H-ras, N-ras and K-ras, generate distinct signal outputs, ...

STAT transcription factor, DNA-binding, subdomain (IPR012345) The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cel...

HR1 rho-binding repeat (IPR011072) The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN). The first two of these repeats were ...

SARAH domain (IPR011524) The SARAH (Sav/Rassf/Hpo) domain is found at the C terminus in three classes of eukaryotic tumour suppressors that give the domain its name. In the Sav (Salvador) and Hpo (Hippo) ...

CheW-like protein (IPR002545) CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which af...

Protein phosphatase 2A, regulatory B subunit, B56 (IPR002554) Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed he...

Protein phosphatase 2A, regulatory subunit PR55 (IPR000009) Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in many cellular processes, including the regulation of metabolic enzymes and proteins involved in signa...

PAS domain (IPR000014) PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain prot...

Obesity factor (IPR000065) Leptin, a metabolic monitor of food intake and energy need, is expressed by the ob obesity gene. The protein may function as part of a signalling pathway from adipose tissue that ...

Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) In Drosophila melanogaster the Toll protein is involved in establishment of dorso-ventral polarity in the embryo. In addition, members of the Toll family play a key role in innate...