Release Notes

Release 27.0, 19th May 2010

Previous release notes

New features include:

  • This release includes an update to PIRSF (2.72) and the integration of 220 new methods from ProDom, Pfam, PIRSF and TIGRFAMs.

  • Please Note: Pfam release 24.0 matches were calculated using HMMER3. The majority of the updated signatures were stable; however some had significant increases or decreases in the numbers of proteins they matched (+/- 30% change), which changed the taxonomy and/or biology based on protein matches. We are reviewing these entries, checking that the InterPro entry annotation is still valid and reflects the taxonomy and biology of the proteins matched by the Pfam signatures. Those Pfam signatures which have not yet been through this review process were therefore temporarily removed from InterPro and will be re-integrated into the InterPro database during 2010. If you have any questions about this, please contact us via support.

Contents and coverage of InterPro 27.0

InterPro protein matches are now calculated for all UniProtKB and UniParc proteins. The following statistics are for all UniProtKB proteins. InterPro release 27.0 contains 20671 entries, representing:

Active site 89
Binding site 62
Conserved site 575
Domain 5515
Family 12718
PTM 16
Region 1441
Repeat 255

Last entry: IPR022762

32095 publications in PUBMED are referenced from InterPro.

Member database information

Signature Database Version Signatures* Integrated Signatures**
GENE3D 3.0.0 2147 1021
HAMAP 280509 1633 621
PANTHER 6.1 30128 2233
PIRSF 2.72 3222 2751
PRINTS 40.0 2000 1954
PROSITE patterns 20.52 1308 1290
PROSITE profiles 20.52 860 836
Pfam 24.0 11912 11285
PfamB 24.0 142303 0
ProDom 2006.1 1894 1011
SMART 6.0 809 801
SUPERFAMILY 1.69 1538 1093
TIGRFAMs 9.0 3808 3795

* Some signatures may not have matches to UniProtKB proteins.

** Not all signatures of a member database may be integrated at the time of an InterPro release.

Sequence Database Version Count count of proteins matching
any signature integrated signatures
UniProtKB 2010_06 11384898 9669145 (84.9%) 8934231 (78.5%)
UniProtKB/TrEMBL 2010_06 10867798 9167041 (84.4%) 8442076 (77.7%)
UniProtKB/Swiss-Prot 2010_06 517100 502104 (97.1%) 492155 (95.2%)

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