Release 26.0, 23rd March 2010

Previous release notes

New features include:

  • This release includes an update to PRINTS (40.0) and the integration of 131 new methods from PRINTS, HAMAP, Pfam, PIRSF and TIGRFAMs.

  • Please Note: Pfam release 24.0 matches were calculated using HMMER3. The majority of the updated signatures were stable; however some had significant increases or decreases in the numbers of proteins they matched (+/- 30% change), which changed the taxonomy and/or biology based on protein matches. We are reviewing these entries, checking that the InterPro entry annotation is still valid and reflects the taxonomy and biology of the proteins matched by the Pfam signatures. Those Pfam signatures which have not yet been through this review process were therefore temporarily removed from InterPro and will be re-integrated into the InterPro database during 2010. If you have any questions about this, please contact us via support.

Contents and coverage of InterPro 26.0

InterPro protein matches are now calculated for all UniProtKB and UniParc proteins. The following statistics are for all UniProtKB proteins. InterPro release 26.0 contains 20329 entries, representing:

Active site 87
Binding site 61
Conserved site 566
Domain 5542
Family 12370
PTM 16
Region 1437
Repeat 250

Last entry: IPR022422

27817 publications in PUBMED are referenced from InterPro.

Member database information

Signature Database Version Signatures* Integrated Signatures**
GENE3D 3.0.0 2147 1023
HAMAP 280509 1633 620
PANTHER 6.1 30128 2234
PIRSF 2.71 3219 2744
PRINTS 40.0 2000 1975
PROSITE patterns 20.52 1308 1292
PROSITE profiles 20.52 860 836
Pfam 24.0 11912 11056
PfamB 24.0 142303 0
ProDom 2006.1 1894 991
RELEASED:Pfam 23.0 10340 0
SMART 6.0 809 803
SUPERFAMILY 1.69 1538 1095
TIGRFAMs 9.0 3808 3689

* Some signatures may not have matches to UniProtKB proteins.

** Not all signatures of a member database may be integrated at the time of an InterPro release.

Sequence Database Version Count count of proteins matching
any signature integrated signatures
UniProtKB 2010_04 11134468 9454614 (84.9%) 8700914 (78.1%)
UniProtKB/TrEMBL 2010_04 10618387 8953496 (84.3%) 8210505 (77.3%)
UniProtKB/Swiss-Prot 2010_04 516081 501118 (97.1%) 490409 (95.0%)

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