Release 19.0, 29 January 2009

New features include:

  • New methods from Pfam, PANTHER, Gene3D and SUPERFAMILY.
  • InterPro has introduced new entry classification rules that affect the typing of entries. Please see the User Manual for further details.
  • A new Protein Focus article has been published on the subject of Collagen. Protein Focus is a new name for the feature formerly known as "Protein of the Month".

General information:

  • Match_complete.xml (UniProtKB) now contains all UniProtKB proteins including those not matching an InterPro signature.
  • UniParc (uniparc_match.tar.gz) and UniMES (unimes_match.tar.gz) matches to InterPro methods have been updated and are available from the ftp site in XML format.

Note: due to the large size of UniParc and UniMES the data has been divided into chunks and the latest updates are provided in these files at each InterPro release.

Contents and coverage of InterPro 19.0

InterPro protein matches are now calculated for all UniProtKB and UniParc proteins. The following statistics are for all UniProtkB proteins. InterPro release 19.0 contains 17412 entries, representing:

Active site 61
Binding site 38
Conserved site 393
Domain 5149
Family 11132
Region 373
PTM 22
Repeat 244

Last entry: IPR018937

29218 publications in PUBMED are referenced from InterPro.

Member database information

Signature Database Version Signatures* Integrated Signatures**
PANTHER 6.1 30127 2121
Pfam 23.0 10340 9544
PIRSF 2.70 3212 2690
PRINTS 38.0 1900 1857
ProDom 2005.1 3538 0
PROSITE patterns 20.35 1316 1311
PROSITE profiles 20.35 801 779
SMART 5.1 724 721
TIGRFAMs 7.0 3423 3395
GENE3D 3.0.0 2147 1018
SUPERFAMILY 1.69 1538 1083

* Some signatures may not have matches to UniProtKB proteins.

** Not all signatures of a member database may be integrated at the time of an InterPro release.

Sequence Database Version Count count of proteins matching
any signature integrated signatures
UniProtKB 14.7 7409116 5956246 (80.4%) 5644181 (76.2%)
UniProt/Swiss-Prot 56.7 408099 391875 (96.0%) 380550 (93.2%)
UniProt/TrEMBL 39.7 7001017 5564371 (79.5%) 5263631 (75.2%)

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