Release NotesRelease 13.1, Tuesday October 17th 2006
R.Apweiler (1), T.K.Attwood (4), A.Bairoch (2), A.Bateman (5), D.Binns (1), P.Bork (8), P.Bucher (3), L.Cerutti (3), R.Copley (13), E.Courcelle (6), U.Das (1), L.Daugherty (1), M.Dibley (7), R.Finn (5), W.Fleischmann (1), J.Gough (11), D.Haft (9), N.Hulo (2), S.Hunter (1), D.Kahn (6), A.Kanapin (1), A. Kejariwal (14), D.Lonsdale (1), R.Lopez (1), I.Letunic (8), M.Madera (12), J.Maslen (1), C.McAnulla (1), J.McDowall (1), J.Mistry (5), A.Mitchell (1,4), N.Mulder (1), A.N.Nikolskaya (10), S.Orchard (1), C.Orengo (7), M.Pagni (3), R. Petryszak (1), C.Sigrist (2), P.D.Thomas (14), D.Wilson (12), C.H.Wu (10), C.Yates (7).
(1) EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
(2) Swiss Institute for Bioinformatics, Geneva, Switzerland;
(3) Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland;
(4) School of Biological Sciences, The University of Manchester, Manchester, UK;
(5) The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
(6) CNRS/INRA, Toulouse, France;
(7) Biochemistry and Molecular Biology Department, University College London, University of London, UK;
(8) Biocomputing Unit, EMBL-Heidelberg, Germany;
(9) The Institute for Genomic Research, Maryland, USA;
(10) Protein Information Resource, Georgetown University Medical Center, Washington, D.C., USA;
(11) Genomic Sciences Centre, RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Japan;
(12) MRC Laboratory of Molecular Biology, Cambridge, UK;
(13) Wellcome Trust Centre for Human Genetics, Oxford, UK;
(14) Computational Biology, SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
The databases Swiss-Prot and TrEMBL (now part of UniProtKB), PROSITE, PRINTS, Pfam and ProDom joined forces to launch an Integrated Documentation Resource of Protein Families, Domains and Functional Sites, abbreviated InterPro. Since then SMART, TIGRFAMs, PIRSF, SUPERFAMILY and more recently PANTHER and Gene3D, have joined InterPro. A detailed description of the project can be found in the user manual.
Changes since last release
- The protein matches have been updated according to the latest update of UniProtKB.
- Match.xml, match_complete.xml and UniParc matches to InterPro methods (uniparc_match.tar.gz) have been updated and are available from the ftp site in XML format. Due to the large size of UniParc the data has been divided into chunks and the latest updates are provided in these files at each InterPro release.
Contents and coverage of the current release
InterPro protein matches are now calculated for all UniProtKB proteins. For more information see UniProtKB.
InterPro release 13.1 contains 13147 entries, representing 3760 domains, 9080 families, 232 repeats, 32 active sites, 22 binding sites and 21 post-translational modification sites. Overall, there are 14041029 InterPro hits from 2702169 UniProtKB protein sequences. A complete list is available from the ftp site.
92.4% of UniProtKB/Swiss-Prot - 216317 of 234112 proteins
76.6% of UniProtKB/TrEMBL - 2485852 of 3244331 proteins
77.7% of UniProtKB - 2702169 of 3478443 proteins
Last entry: IPR014023
23000 publications in PUBMED are referenced from InterPro.
Lists of InterPro entries by type and to GO
The next release of InterPro will be scheduled for November/December 2006.