Release Notes

Release 13.1, Tuesday October 17th 2006

http://www.ebi.ac.uk/interpro/
ftp://ftp.ebi.ac.uk/pub/databases/interpro/

Acknowledgements

R.Apweiler (1), T.K.Attwood (4), A.Bairoch (2), A.Bateman (5), D.Binns (1), P.Bork (8), P.Bucher (3), L.Cerutti (3), R.Copley (13), E.Courcelle (6), U.Das (1), L.Daugherty (1), M.Dibley (7), R.Finn (5), W.Fleischmann (1), J.Gough (11), D.Haft (9), N.Hulo (2), S.Hunter (1), D.Kahn (6), A.Kanapin (1), A. Kejariwal (14), D.Lonsdale (1), R.Lopez (1), I.Letunic (8), M.Madera (12), J.Maslen (1), C.McAnulla (1), J.McDowall (1), J.Mistry (5), A.Mitchell (1,4), N.Mulder (1), A.N.Nikolskaya (10), S.Orchard (1), C.Orengo (7), M.Pagni (3), R. Petryszak (1), C.Sigrist (2), P.D.Thomas (14), D.Wilson (12), C.H.Wu (10), C.Yates (7).

(1) EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
(2) Swiss Institute for Bioinformatics, Geneva, Switzerland;
(3) Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland;
(4) School of Biological Sciences, The University of Manchester, Manchester, UK;
(5) The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
(6) CNRS/INRA, Toulouse, France;
(7) Biochemistry and Molecular Biology Department, University College London, University of London, UK;
(8) Biocomputing Unit, EMBL-Heidelberg, Germany;
(9) The Institute for Genomic Research, Maryland, USA;
(10) Protein Information Resource, Georgetown University Medical Center, Washington, D.C., USA;
(11) Genomic Sciences Centre, RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Japan;
(12) MRC Laboratory of Molecular Biology, Cambridge, UK;
(13) Wellcome Trust Centre for Human Genetics, Oxford, UK;
(14) Computational Biology, SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.

Current Release

Introduction

The databases Swiss-Prot and TrEMBL (now part of UniProtKB), PROSITE, PRINTS, Pfam and ProDom joined forces to launch an Integrated Documentation Resource of Protein Families, Domains and Functional Sites, abbreviated InterPro. Since then SMART, TIGRFAMs, PIRSF, SUPERFAMILY and more recently PANTHER and Gene3D, have joined InterPro. A detailed description of the project can be found in the user manual.

Changes since last release

Contents and coverage of the current release

InterPro protein matches are now calculated for all UniProtKB proteins. For more information see UniProtKB.

InterPro release 13.1 contains 13147 entries, representing 3760 domains, 9080 families, 232 repeats, 32 active sites, 22 binding sites and 21 post-translational modification sites. Overall, there are 14041029 InterPro hits from 2702169 UniProtKB protein sequences. A complete list is available from the ftp site.

DATABASE VERSION ENTRIES
PANTHER 6.0 1135
Pfam 20.0 8295
PIRSF 2.68 1033
PRINTS 38.0 1899
ProDom 2005.1 1001
PROSITE 19.30 1942
SMART 5.0 704
TIGRFAMs 5.0 2615
GENE3D 3.0 410
SUPERFAMILY 1.65 450
UniProt/Swiss-Prot 50.7 234112
UniProt/TrEMBL 33.7 3244331
InterPro 13.1 13147
GO Classification N/A 20531

92.4% of UniProtKB/Swiss-Prot - 216317 of 234112 proteins

76.6% of UniProtKB/TrEMBL - 2485852 of 3244331 proteins

77.7% of UniProtKB - 2702169 of 3478443 proteins

Last entry: IPR014023

23000 publications in PUBMED are referenced from InterPro.

Lists of InterPro entries by type and to GO

  • Family - Domain - Repeat - PTM - Binding Site - Active Site
  • List of InterPro to GO mappings. These are also available through the EBI GO browser QuickGO
  • Forthcoming changes

    The next release of InterPro will be scheduled for November/December 2006.