Release NotesRelease 12.0, Friday November 18th 2005
R.Apweiler (1), T.K.Attwood (4), A.Bairoch (2), A.Bateman (5), D.Binns (1), P.Bork (8), P.Bucher (3), M.J.Campbell (14), L.Cerutti (3), R.Copley (13), E.Courcelle (6), U.Das (1), L.Daugherty (1), M.Dibley (7), R.Finn (5), W.Fleischmann (1), J.Gough (11), D.Haft (9), N.Hulo (2), S.Hunter (1), D.Kahn (6), A.Kanapin (1), M.Krestyaninova (1), D.Lonsdale (1), R.Lopez (1), I.Letunic (8), M.Madera (12), J.Maslen (1), C.McAnulla (1), J.McDowall (1), J.Mistry (5), A.Mitchell (1,4), N.Mulder (1), A.N.Nikolskaya (10), S.Orchard (1), C.Orengo (7), M.Pagni (3), C.Sigrist (2), P.D.Thomas (14), D.Wison (12), C.H.Wu (10), C.Yates (7).
(1) EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
(2) Swiss Institute for Bioinformatics, Geneva, Switzerland;
(3) Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland;
(4) School of Biological Sciences, The University of Manchester, Manchester, UK;
(5) The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
(6) CNRS/INRA, Toulouse, France;
(7) Biochemistry and Molecular Biology Department, University College London, University of London, UK;
(8) Biocomputing Unit, EMBL-Heidelberg, Germany;
(9) The Institute for Genomic Research, Maryland, USA;
(10) Protein Information Resource, Georgetown University Medical Center, Washington, D.C., USA;
(11) Genomic Sciences Centre, RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Japan;
(12) MRC Laboratory of Molecular Biology, Cambridge, UK;
(13) Wellcome Trust Centre for Human Genetics, Oxford, UK;
(14) Computational Biology, Applied Biosystems, 850 Lincoln Center Drive, Foster City, CA 94404, USA.
The databases Swiss-Prot and TrEMBL (now part of UniProtKB), PROSITE, PRINTS, Pfam and ProDom joined forces to launch an Integrated Documentation Resource of Protein Families, Domains and Functional Sites, abbreviated InterPro. Since then SMART, TIGRFAMs, PIRSF, SUPERFAMILY and more recently PANTHER and Gene3D, have joined InterPro. A detailed description of the project can be found in the user manual.
Changes since last release
The protein matches have been updated according to the latest update of UniProtKB and new methods from Gene3D, Pfam, PRINTS, PROSITE and SMART have been integrated
- Additional reading, linked to abstracts
- Taxonomy; increase in taxonomy lineages display link to the graphical views
Contents and coverage of the current release
InterPro protein matches are now calculated for all UniProtKB proteins, which are a combination of UniProtKB/Swiss-Prot, UniProtKB/TrEMBL and PIR proteins. For more information see UniProtKB.
InterPro release 12.0 contains 12542 entries, representing 3289 domains, 8945 families, 234 repeats, 32 active sites, 21 binding sites and 21 post-translational modification sites. Overall, there are 10123516 InterPro hits from 1966591 UniProt protein sequences. A complete list is available from the ftp site.
92.0% of UniProtKB/Swiss-Prot - 181542 of 197228 proteins
76.2% of UniProtKB/TrEMBL - 1785049 of 2342938 proteins
77.4% of UniProtKB - 1966591 of 2540166 proteins
Last entry: IPR013333
20692 publications in PUBMED are referenced from InterPro.
The next release of InterPro will be release 12.1 scheduled for February 2006. It will incorporate:
- Links to Pfam Clan pages
- Links to IntAct
- Links to NCBI COGS