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CREB-binding protein (Q92793)

Accession
Q92793 (CBP_HUMAN)
Species
Homo sapiens (Human)
Length
2,442 amino acids (complete)
Source: UniProtKB

Protein family membership

Homologous superfamilies

  1. Homologous superfamily
  2. Homologous superfamily
1 500 1000 1500 2000 2442

Domains and repeats

  1. Domain
  2. Domain
1 500 1000 1500 2000 2442

Detailed signature matches

  1. Homologous superfamily IPR035898
    TAZ domain superfamily
    1. G3DSA:1.20.10...
    2. SSF57933
  2. Homologous superfamily IPR036529
    Coactivator CBP, KIX domain superfamily
    1. SSF47040
  3. Homologous superfamily IPR036427
    Bromodomain-like superfamily
    1. SSF47370
    2. G3DSA:1.20.92...
  4. Homologous superfamily IPR038547
    CBP/p300, atypical RING domain superfamily
    1. G3DSA:2.10.11...
  5. Homologous superfamily IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  6. Homologous superfamily IPR037073
    Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
    1. G3DSA:1.10.16...
  7. Homologous superfamily IPR009110
    Nuclear receptor coactivator, interlocking
    1. SSF69125
  8. Family IPR013178
    Histone acetyltransferase Rtt109/CBP
    1. PF08214 (HAT_KAT11)
    2. SM01250 (KAT11)
  9. Domain IPR000197
    Zinc finger, TAZ-type
    1. PS50134 (ZF_TAZ)
    2. SM00551 (ZnF_TAZ)
    3. PF02135 (zf-TAZ)
  10. Domain IPR003101
    Coactivator CBP, KIX domain
    1. PF02172 (KIX)
    2. PS50952 (KIX)
  11. Domain IPR001487
    Bromodomain
    1. PS50014 (BROMODOMAIN_2)
    2. SM00297 (BROMO)
    3. PF00439 (Bromodomain)
    4. PR00503 (BROMODOMAIN)
  12. Domain IPR010303
    CREB-binding protein/p300, atypical RING domain
    1. PF06001 (DUF902)
    2. cd15802 (RING_CBP-p300)
  13. Domain IPR031162
    CBP/p300-type histone acetyltransferase domain
    1. PS51727 (CBP_P300_HAT)
  14. Domain IPR000433
    Zinc finger, ZZ-type
    1. PS01357 (ZF_ZZ_1)
    2. PF00569 (ZZ)
    3. PS50135 (ZF_ZZ_2)
    4. SM00291 (ZnF_ZZ)
  15. Domain IPR014744
    Nuclear receptor coactivator, CREB-bp-like, interlocking
    1. PF09030 (Creb_binding)
  16. SITE IPR018359
    Bromodomain, conserved site
    1. PS00633 (BROMODOMAIN_1)

Residue annotation

  1. acetyllysine bindi...
  2. HAT interface cd15...
  3. Zn binding site cd...
  4. putative histone H...
  5. zinc cluster 1 cd0...
  6. Zinc-binding sites...
  7. putative charged b...
  8. putative hydrophob...
  9. zinc cluster 2 cd0...

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation

Molecular Function

GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding

Cellular Component

GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus