Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (P60484)

Homo sapiens (Human)
403 amino acids (complete)
Source: UniProtKB

Protein family membership

Homologous superfamilies

  1. Homologous superfamily
1 50 100 150 200 250 300 350 403

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 403

Detailed signature matches

GO term prediction

Biological Process

GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0016311 dephosphorylation
GO:0030336 negative regulation of cell migration
GO:0031647 regulation of protein stability
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0051895 negative regulation of focal adhesion assembly
GO:0051898 negative regulation of protein kinase B signaling

Molecular Function

GO:0000287 magnesium ion binding
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0030165 PDZ domain binding
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

Cellular Component

None predicted.