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Transcription activator BRG1 (P51532)

Accession
P51532 (SMCA4_HUMAN)
Species
Homo sapiens (Human)
Length
1,647 amino acids (complete)
Source: UniProtKB

Protein family membership

Homologous superfamilies

  1. Homologous superfamily
  2. Homologous superfamily
1 200 400 600 800 1000 1200 1400 1647

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1647

Detailed signature matches

  1. Homologous superfamily IPR037259
    BRK domain superfamily
    1. G3DSA:2.20.28...
    2. SSF160481
  2. Homologous superfamily IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540
  3. Homologous superfamily IPR038718
    SNF2-like, N-terminal domain superfamily
    1. G3DSA:3.40.50...
  4. Homologous superfamily IPR036427
    Bromodomain-like superfamily
    1. SSF47370
    2. G3DSA:1.20.92...
  5. Family IPR030100
    SWI/SNF complex subunit BRG1
    1. PTHR10799:SF76
  6. Domain IPR014978
    Glutamine-Leucine-Glutamine, QLQ
    1. PS51666 (QLQ)
    2. PF08880 (QLQ)
    3. SM00951 (QLQ)
  7. Domain IPR014012
    Helicase/SANT-associated domain
    1. PS51204 (HSA)
    2. SM00573 (HSA)
    3. PF07529 (HSA)
  8. Domain IPR006576
    BRK domain
    1. SM00592 (BRK)
    2. PF07533 (BRK)
  9. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. SM00487 (DEXDc)
    2. PS51192 (HELICASE_A...)
  10. Domain IPR000330
    SNF2-related, N-terminal domain
    1. PF00176 (SNF2_N)
  11. Domain IPR001650
    Helicase, C-terminal
    1. SM00490 (HELICc)
    2. PF00271 (Helicase_C)
    3. cd00079 (HELICc)
    4. PS51194 (HELICASE_CTER)
  12. Domain IPR029295
    Snf2, ATP coupling domain
    1. PF14619 (SnAC)
    2. SM01314 (SnAC)
  13. Domain IPR001487
    Bromodomain
    1. SM00297 (BROMO)
    2. PS50014 (BROMODOMAIN_2)
    3. PF00439 (Bromodomain)
    4. PR00503 (BROMODOMAIN)
  14. SITE IPR018359
    Bromodomain, conserved site
    1. PS00633 (BROMODOMAIN_1)

Residue annotation

  1. ATP binding site c...
  2. putative Mg++ bind...
  3. nucleotide binding...
  4. ATP-binding site c...
  5. acetyllysine bindi...

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0043044 ATP-dependent chromatin remodeling

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016887 ATPase activity
GO:0042393 histone binding

Cellular Component

GO:0005634 nucleus
GO:0016514 SWI/SNF complex