Structures: Nicotinamide phosphoribosyltransferase (P43490)

Accession
P43490 (NAMPT_HUMAN)
Species
Homo sapiens (Human)
Length
491 amino acids (complete)
Source: UniProtKB


Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 491

Structural features and predictions

  1. no IPR
    Structural features
    1. CATH
    2. PDB

Solved structures for this protein

ID Structure Description
2e5b Structure image for 2e5b Crystal structure of Human NMPRTase as free-form
4o18 Structure image for 4o18 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
5upf Structure image for 5upf Crystal structure of human NAMPT with isoindoline urea inhibitor compound 53
6azj Structure image for 6azj Crystal Structure of human NAMPT in complex with NVP-LQN520
5upe Structure image for 5upe Crystal structure of human NAMPT with isoindoline urea inhibitor compound 5
2gvj Structure image for 2gvj Crystal Structure of Human NMPRTase in complex with FK866
4lvg Structure image for 4lvg Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4o13 Structure image for 4o13 The crystal structure of NAMPT in complex with GNE-618
4o15 Structure image for 4o15 The crystal structure of a mutant NAMPT (S165F) in complex with GNE-618
5wi0 Structure image for 5wi0 Crystal structure of human NAMPT with fragment 2: 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one
3dgr Structure image for 3dgr Crystal structure of human NAMPT complexed with ADP analogue
4n9e Structure image for 4n9e Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4l4m Structure image for 4l4m Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase
4o10 Structure image for 4o10 Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase
4o1b Structure image for 4o1b The crystal structure of a mutant NAMPT (G217R) in complex with an inhibitor APO866
5u2m Structure image for 5u2m Crystal structure of human NAMPT with A-1293201
6atb Structure image for 6atb Crystal Structure of human NAMPT in complex with NVP-LOD812
6e68 Structure image for 6e68 NAMPT co-crystal with inhibitor compound 2
4lvd Structure image for 4lvd Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
2e5d Structure image for 2e5d Crystal structure of Human NMPRTase complexed with nicotinamide
4lv9 Structure image for 4lv9 Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4m6p Structure image for 4m6p Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4n9c Structure image for 4n9c Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
5lx3 Structure image for 5lx3 CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782.
4lts Structure image for 4lts Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
4o12 Structure image for 4o12 Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase
6b75 Structure image for 6b75 Crystal Structure of human NAMPT in complex with NVP-LOQ594
4lva Structure image for 4lva Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4o17 Structure image for 4o17 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
3dhf Structure image for 3dhf Crystal structure of phosphorylated mimic form of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate
4n9d Structure image for 4n9d Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4wq6 Structure image for 4wq6 The crystal structure of human Nicotinamide phosphoribosyltransferase (NAMPT) in complex with N-(4-{(S)-[1-(2-methylpropyl)piperidin-4-yl]sulfinyl}benzyl)furo[2,3-c]pyridine-2-carboxamide inhibitor (compound 21)
2e5c Structure image for 2e5c Crystal structure of Human NMPRTase complexed with 5'-phosphoribosyl-1'-pyrophosphate
4m6q Structure image for 4m6q Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4n9b Structure image for 4n9b Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4o16 Structure image for 4o16 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
2gvg Structure image for 2gvg Crystal Structure of human NMPRTase and its complex with NMN
4jnm Structure image for 4jnm Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
4kfn Structure image for 4kfn Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
4kfp Structure image for 4kfp Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4o0z Structure image for 4o0z Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase
4o14 Structure image for 4o14 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
5kit Structure image for 5kit Crystal Structure of Nicotinamide Phosphoribosyltransferase (Nampt) in Complex with Inhibitors 37
5u2n Structure image for 5u2n Crystal structure of human NAMPT with A-1326133
5wi1 Structure image for 5wi1 Crystal structure of human NAMPT with fragment 5: (3E)-3-[(phenylamino)methylidene]oxan-2-one
4kfo Structure image for 4kfo Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
6b76 Structure image for 6b76 Crystal Structure of human NAMPT in complex with NVP-LVR596
4lww Structure image for 4lww Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
4o1d Structure image for 4o1d Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
3dkl Structure image for 3dkl Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate
4l4l Structure image for 4l4l Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase
4lvb Structure image for 4lvb Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4o19 Structure image for 4o19 The crystal structure of a mutant NAMPT (G217V)
4o1a Structure image for 4o1a The crystal structure of the mutant NAMPT G217R
4o28 Structure image for 4o28 Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
3dhd Structure image for 3dhd Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate
3dkj Structure image for 3dkj Crystal structure of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate
4jr5 Structure image for 4jr5 Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
4lvf Structure image for 4lvf Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
4o1c Structure image for 4o1c The crystal structures of a mutant NAMPT H191R
5lx5 Structure image for 5lx5 CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP.
5nsd Structure image for 5nsd Co-crystal structure of NAMPT dimer with KPT-9274