Structures: TGF-beta receptor type-1 (P36897)

Accession
P36897 (TGFR1_HUMAN)
Species
Homo sapiens (Human)
Length
503 amino acids (complete)
Source: UniProtKB


Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 503

Structural features and predictions

  1. no IPR
    Structural features
    1. CATH
    2. PDB
    3. SCOP
  1. no IPR
    Structural predictions
    1. MODBASE

Solved structures for this protein

ID Structure Description
5e90 Structure image for 5e90 TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F, S280T,Y282F,S287N,A350C,L352F) IN COMPLEX WITH 3-AMINO-6- [4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE
5e8t Structure image for 5e8t TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D)
5usq Structure image for 5usq ALK-5 kinase inhibitor complex
4x2g Structure image for 4x2g Selection of fragments for kinase inhibitor design: decoration is key
3kfd Structure image for 3kfd Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
5fri Structure image for 5fri ALK5 in complex witha an N-(4-anilino-2-pyridyl)acetamide inhibitor.
3gxl Structure image for 3gxl ALK-5 kinase complex with GW857175
5e8u Structure image for 5e8u TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F)
4x2j Structure image for 4x2j Selection of fragments for kinase inhibitor design: decoration is key
5e8w Structure image for 5e8w TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH STAUROSPORINE
2x7o Structure image for 2x7o Crystal structure of TGFbRI complexed with an indolinone inhibitor
5e8x Structure image for 5e8x TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) IN COMPLEX WITH STAUROSPORINE
4x2f Structure image for 4x2f Selection of fragments for kinase inhibitor design: decoration is key
3tzm Structure image for 3tzm TGF-beta Receptor type 1 in complex with SB431542
1vjy Structure image for 1vjy Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor
1b6c Structure image for 1b6c CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12
4x2n Structure image for 4x2n Selection of fragments for kinase inhibitor design: decoration is key
3faa Structure image for 3faa Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor
5e8s Structure image for 5e8s TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (WT)
2wot Structure image for 2wot ALK5 IN COMPLEX WITH 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine
2pjy Structure image for 2pjy Structural basis for cooperative assembly of the TGF-beta signaling complex
4x2k Structure image for 4x2k Selection of fragments for kinase inhibitor design: decoration is key
3hmm Structure image for 3hmm Structure of Alk5 + GW855857
5e8z Structure image for 5e8z TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH 3-AMINO-6-[4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE
2wou Structure image for 2wou ALK5 IN COMPLEX WITH 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2-pyridyl) amino)benzenesulfonamide
2l5s Structure image for 2l5s Solution structure of the extracellular domain of the TGF-beta type I receptor
1py5 Structure image for 1py5 Crystal Structure of TGF-beta receptor I kinase with inhibitor
4x0m Structure image for 4x0m Selection of fragments for kinase inhibitor design: decoration is key
3kcf Structure image for 3kcf Crystal structure of TGFbRI complexed with a pyrazolone inhibitor
1ias Structure image for 1ias CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12
1rw8 Structure image for 1rw8 Crystal Structure of TGF-beta receptor I kinase with ATP site inhibitor