1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (P19174)

Accession
P19174 (PLCG1_HUMAN)
Species
Homo sapiens (Human)
Length
1,290 amino acids (complete)
Source: UniProtKB


Protein family membership

Homologous superfamilies

  1. Homologous superfamily
  2. Homologous superfamily
  3. Homologous superfamily
1 200 400 600 800 1000 1290

Domains and repeats

1 200 400 600 800 1000 1290

Detailed signature matches

    1. PIRSF000952 (PLC-gamma)
    1. PS50222 (EF_HAND_2)
    1. PF00388 (PI-PLC-X)
    2. SM00148 (PLCXc)
    3. PS50007 (PIPLC_X_DO...)
    1. cd10341 (SH2_N-SH2_...)
    1. cd09932 (SH2_C-SH2_...)
    1. cd11970 (SH3_PLCgamma1)
    1. SM00149 (PLCYc)
    2. PF00387 (PI-PLC-Y)
    3. PS50008 (PIPLC_Y_DO...)
    1. PS00018 (EF_HAND_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00275 (C2_PLC_like)
  2. cd08592 (PI-PLCc_gamma)
  3. cd13234 (PHsplit_PL...)
  4. cd13362 (PH_PLC_gamma)
  5. cd16214 (EFh_PI-PLC...)
  6. mobidb-lite (disord...)

Residue annotation

  1. putative Rac1 bind...
  2. putative phosphoin...
  3. catalytic site cd0...
  4. putative active si...
  5. putative Ca bindin...
  6. phosphotyrosine bi...
  7. hydrophobic bindin...
  8. phosphotyrosine bi...
  9. hydrophobic bindin...
  10. peptide ligand bin...
  11. Rac2 binding site ...
  12. Ca2+ binding pocke...

GO term prediction

Biological Process

GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0009395 phospholipid catabolic process
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity

Cellular Component

None predicted.