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Metalloproteinase inhibitor 2 (P16035)

Accession
P16035 (TIMP2_HUMAN)
Species
Homo sapiens (Human)
Length
220 amino acids (complete)
Source: UniProtKB

Protein family membership

Homologous superfamilies

  1. Homologous superfamily
  2. Homologous superfamily
1 50 100 150 220

Domains and repeats

  1. Domain
1 50 100 150 220

Detailed signature matches

  1. Homologous superfamily IPR027465
    Proteinase inhibitor I35b (TIMP), C-terminal
    1. G3DSA:3.90.37...
  2. Homologous superfamily IPR008993
    Tissue inhibitor of metalloproteinases-like, OB-fold
    1. SSF50242
  3. Family IPR001820
    Protease inhibitor I35 (TIMP)
    1. PF00965 (TIMP)
    2. PTHR11844
    3. SM00206 (NTR)
  4. Family IPR015613
    Metalloproteinase inhibitor 2
    1. PTHR11844:SF24
  5. Domain IPR001134
    Netrin domain
    1. PS50189 (NTR)
  6. SITE IPR030490
    Tissue inhibitor of metalloproteinase, conserved site
    1. PS00288 (TIMP)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. cd03585 (NTR_TIMP)

Other features

  1. NON_CYTOPLASM...
  2. SIGNAL_PEPTIDE
  3. SIGNAL_PEPTID...
  4. SIGNAL_PEPTID...
  5. SIGNAL_PEPTID...
  6. SignalP-TM
  7. SignalP-noTM

GO term prediction

Biological Process

GO:0010951 negative regulation of endopeptidase activity

Molecular Function

GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity

Cellular Component

None predicted.