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Thyroid hormone receptor alpha (P10827)

Accession
P10827 (THA_HUMAN)
Species
Homo sapiens (Human)
Length
490 amino acids (complete)
Source: UniProtKB

Protein family membership

Homologous superfamilies

  1. Homologous superfamily
  2. Homologous superfamily
1 50 100 150 200 250 300 350 400 450 490

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 490

Detailed signature matches

  1. Homologous superfamily IPR013088
    Zinc finger, NHR/GATA-type
    1. G3DSA:3.30.50.10
  2. Homologous superfamily IPR035500
    Nuclear hormone receptor-like domain superfamily
    1. SSF48508
  3. Family IPR001723
    Nuclear hormone receptor
    1. PR00398 (STRDHORMONER)
  4. Family IPR001728
    Thyroid hormone receptor
    1. PR00546 (THYROIDHORMR)
  5. Domain IPR001628
    Zinc finger, nuclear hormone receptor-type
    1. PF00105 (zf-C4)
    2. PS00031 (NUCLEAR_RE...)
    3. PS51030 (NUCLEAR_RE...)
    4. PR00047 (STROIDFINGER)
    5. SM00399 (ZnF_C4)
  6. Domain IPR000536
    Nuclear hormone receptor, ligand-binding domain
    1. SM00430 (HOLI)
    2. PF00104 (Hormone_recep)

Residue annotation

  1. zinc binding site ...
  2. heterodimer interf...
  3. DNA binding site c...
  4. ligand binding sit...
  5. coactivator recogn...
  6. dimer interface cd...

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated
GO:0043401 steroid hormone mediated signaling pathway

Molecular Function

GO:0003677 DNA binding
GO:0003700 DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004887 thyroid hormone receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding

Cellular Component

GO:0005634 nucleus