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Proto-oncogene tyrosine-protein kinase ROS (P08922)

Accession
P08922 (ROS1_HUMAN)
Species
Homo sapiens (Human)
Length
2,347 amino acids (complete)
Source: UniProtKB

Protein family membership

None predicted.

Homologous superfamilies

  1. Homologous superfamily
  2. Homologous superfamily
1 500 1000 1500 2000 2347

Domains and repeats

  1. Domain
  2. Repeat
1 500 1000 1500 2000 2347

Detailed signature matches

  1. Homologous superfamily IPR013783
    Immunoglobulin-like fold
    1. G3DSA:2.60.40.10
  2. Homologous superfamily IPR036116
    Fibronectin type III superfamily
    1. SSF49265
  3. Homologous superfamily IPR011042
    Six-bladed beta-propeller, TolB-like
    1. G3DSA:2.120.1...
  4. Homologous superfamily IPR011009
    Protein kinase-like domain superfamily
    1. SSF56112
  5. Domain IPR003961
    Fibronectin type III
    1. cd00063 (FN3)
    2. SM00060 (FN3)
    3. PF00041 (fn3)
    4. PS50853 (FN3)
  6. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
  7. Domain IPR001245
    Serine-threonine/tyrosine-protein kinase, catalytic domain
    1. PR00109 (TYRKINASE)
    2. PF07714 (Pkinase_Tyr)
  8. Domain IPR020635
    Tyrosine-protein kinase, catalytic domain
    1. SM00219 (TyrKc)
  9. Repeat IPR000033
    LDLR class B repeat
    1. SM00135 (LY)
  10. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  11. SITE IPR008266
    Tyrosine-protein kinase, active site
    1. PS00109 (PROTEIN_KI...)
  12. SITE IPR002011
    Tyrosine-protein kinase, receptor class II, conserved site
    1. PS00239 (RECEPTOR_T...)

Residue annotation

  1. Interdomain contac...
  2. Cytokine receptor ...
  3. Interdomain contac...
  4. Cytokine receptor ...
  5. Interdomain contac...
  6. Cytokine receptor ...
  7. Interdomain contac...
  8. Cytokine receptor ...
  9. Interdomain contac...
  10. Cytokine receptor ...
  11. Interdomain contac...
  12. Cytokine receptor ...
  13. Interdomain contac...
  14. Cytokine receptor ...
  15. ATP binding site c...
  16. active site cd05044
  17. polypeptide substr...
  18. activation loop (A...

GO term prediction

Biological Process

GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

Molecular Function

GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0016020 membrane