Structures: Aurora kinase A (O14965)

Accession
O14965 (AURKA_HUMAN)
Species
Homo sapiens (Human)
Length
403 amino acids (complete)
Source: UniProtKB


Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 403

Structural features and predictions

  1. no IPR
    Structural features
    1. CATH
    2. PDB
    3. SCOP

Solved structures for this protein

ID Structure Description
2bmc Structure image for 2bmc Aurora-2 T287D T288D complexed with PHA-680632
3uoh Structure image for 3uoh Aurora A in complex with RPM1722
4uzd Structure image for 4uzd SAR156497 an exquisitely selective inhibitor of Aurora kinases
4uzh Structure image for 4uzh SAR156497 an exquisitely selective inhibitor of Aurora kinases
5aad Structure image for 5aad Aurora A kinase bound to an imidazopyridine inhibitor (7a)
5dr2 Structure image for 5dr2 Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122
5dt0 Structure image for 5dt0 Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122
5os0 Structure image for 5os0 Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
6hjk Structure image for 6hjk Crystal Structure of Aurora-A L210C catalytic domain in complex with ASDO2
2c6e Structure image for 2c6e Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor
2np8 Structure image for 2np8 Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
2xru Structure image for 2xru AURORA-A T288E COMPLEXED WITH PHA-828300
3p9j Structure image for 3p9j Aurora A kinase domain with phthalazinone pyrazole inhibitor
3up2 Structure image for 3up2 Aurora A in complex with RPM1686
3w2c Structure image for 3w2c Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV
4byi Structure image for 4byi Aurora A kinase bound to a highly selective imidazopyridine inhibitor
4dee Structure image for 4dee Aurora A in complex with ADP
5aaf Structure image for 5aaf Aurora A kinase bound to an imidazopyridine inhibitor (14a)
5dpv Structure image for 5dpv Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122
5ose Structure image for 5ose Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
1ol7 Structure image for 1ol7 Structure of Human Aurora-A 122-403 phosphorylated on Thr287, Thr288
2dwb Structure image for 2dwb Aurora-A kinase complexed with AMPPNP
2w1d Structure image for 2w1d Structure determination of Aurora Kinase in complex with inhibitor
2w1e Structure image for 2w1e Structure determination of Aurora Kinase in complex with inhibitor
2w1f Structure image for 2w1f Structure determination of Aurora Kinase in complex with inhibitor
2xne Structure image for 2xne Structure of Aurora-A bound to an imidazopyrazine inhibitor
3k5u Structure image for 3k5u Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor
3qbn Structure image for 3qbn Structure of Human Aurora A in Complex with a diaminopyrimidine
3uo5 Structure image for 3uo5 Aurora A in complex with YL1-038-31
4deb Structure image for 4deb Aurora A in complex with RK2-17-01
5aae Structure image for 5aae Aurora A kinase bound to an imidazopyridine inhibitor (14d)
5lxm Structure image for 5lxm Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2
5one Structure image for 5one Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)
5orr Structure image for 5orr Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5os1 Structure image for 5os1 Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
2c6d Structure image for 2c6d Aurora A kinase activated mutant (T287D) in complex with ADPNP
2j4z Structure image for 2j4z Structure of Aurora-2 in complex with PHA-680626
2w1g Structure image for 2w1g Structure determination of Aurora Kinase in complex with inhibitor
2x81 Structure image for 2x81 STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054
5dr6 Structure image for 5dr6 Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122
5g1x Structure image for 5g1x Crystal structure of Aurora-A kinase in complex with N-Myc
5orz Structure image for 5orz Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
6cpf Structure image for 6cpf Structure of dephosphorylated Aurora A (122-403) bound to AMPPCP in an active conformation
2wtv Structure image for 2wtv Aurora-A Inhibitor Structure
3uok Structure image for 3uok Aurora A in complex with YL5-81-1
4jai Structure image for 4jai Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide
4zs0 Structure image for 4zs0 Human Aurora A catalytic domain bound to SB-6-OH
5obr Structure image for 5obr Aurora A kinase in complex with 2-(3-chloro-5-fluorophenyl)quinoline-4-carboxylic acid and JNJ-7706621
5orn Structure image for 5orn Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5ory Structure image for 5ory Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
1ol5 Structure image for 1ol5 Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43
2wtw Structure image for 2wtw Aurora-A Inhibitor Structure (2nd crystal form)
3h0z Structure image for 3h0z Aurora A in complex with a bisanilinopyrimidine
3nrm Structure image for 3nrm Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors
3uod Structure image for 3uod Aurora A in complex with RPM1693
3w18 Structure image for 3w18 Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XIII
4bn1 Structure image for 4bn1 Crystal structure of V174M mutant of Aurora-A kinase
4byj Structure image for 4byj Aurora A kinase bound to a highly selective imidazopyridine inhibitor
4ded Structure image for 4ded Aurora A in complex with YL1-038-21
4ztq Structure image for 4ztq Human Aurora A catalytic domain bound to FK932
2x6e Structure image for 2x6e Aurora-A bound to an inhibitor
3unz Structure image for 3unz Aurora A in Complex with RPM1679
4b0g Structure image for 4b0g Complex of Aurora-A bound to an Imidazopyridine-based inhibitor
4dea Structure image for 4dea Aurora A in complex with YL1-038-18
4o0w Structure image for 4o0w Crystal structures of human kinase Aurora A
4prj Structure image for 4prj Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)
5aag Structure image for 5aag Aurora A kinase bound to an imidazopyridine inhibitor (14b)
5dos Structure image for 5dos Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122
5obj Structure image for 5obj Aurora A kinase in complex with 2-(3-fluorophenyl)quinoline-4-carboxylic acid and ATP
5orw Structure image for 5orw Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5os4 Structure image for 5os4 Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
4ceg Structure image for 4ceg Crystal structure of Aurora A 122-403 C290A, C393A bound to ADP
4j8m Structure image for 4j8m Aurora A in complex with CD532
5dt4 Structure image for 5dt4 Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122
5g15 Structure image for 5g15 Structure Aurora A (122-403) bound to activating monobody Mb1 and AMPPCP
6cpe Structure image for 6cpe Structure of apo, dephosphorylated Aurora A (122-403) in an active conformation
2xng Structure image for 2xng Structure of Aurora-A bound to a selective imidazopyrazine inhibitor
3o51 Structure image for 3o51 Crystal structure of anthranilamide 10 bound to AuroraA
3w10 Structure image for 3w10 Aurora kinase A complexed to pyrazole aminoquinoline I
4j8n Structure image for 4j8n Aurora A Kinase Apo
5dr9 Structure image for 5dr9 Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122
5ew9 Structure image for 5ew9 Crystal Structure of Aurora A Kinase Domain Bound to MK-5108
5odt Structure image for 5odt Aurora-A in complex with TACC3
1mq4 Structure image for 1mq4 Crystal Structure of Aurora-A Protein Kinase
1muo Structure image for 1muo CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE
3coh Structure image for 3coh Crystal structure of Aurora-A in complex with a pentacyclic inhibitor
4dhf Structure image for 4dhf Structure of Aurora A mutant bound to Biogenidec cpd 15
4jaj Structure image for 4jaj Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE
4jbq Structure image for 4jbq Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
4o0u Structure image for 4o0u Crystal structures of human kinase Aurora A
5orl Structure image for 5orl Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5os3 Structure image for 5os3 Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
3e5a Structure image for 3e5a Crystal structure of Aurora A in complex with VX-680 and TPX2
3o50 Structure image for 3o50 Crystal structure of benzamide 9 bound to AuroraA
3r21 Structure image for 3r21 Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
3uol Structure image for 3uol Aurora A in complex with SO2-162
3up7 Structure image for 3up7 Aurora A in complex with YL1-038-09
4c3r Structure image for 4c3r Structure of dephosphorylated Aurora A (122-403) bound to AMPPCP
4jbp Structure image for 4jbp Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
5dnr Structure image for 5dnr Aurora A Kinase in complex with ATP in space group P41212
6cpg Structure image for 6cpg Structure of dephosphorylated Aurora A (122-403) in complex with inhibiting monobody and AT9283 in an inactive conformation
2x6d Structure image for 2x6d Aurora-A bound to an inhibitor
3m11 Structure image for 3m11 Crystal Structure of Aurora A Kinase complexed with inhibitor
3r22 Structure image for 3r22 Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
3vap Structure image for 3vap Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity
4o0s Structure image for 4o0s Crystal structures of human kinase Aurora A
4uyn Structure image for 4uyn SAR156497 an exquisitely selective inhibitor of Aurora kinases
5dt3 Structure image for 5dt3 Aurora A Kinase in Complex with ATP in Space Group P6122
5l8l Structure image for 5l8l Aurora-A kinase domain in complex with vNAR-D01 (crystal form 1)
5orp Structure image for 5orp Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5ors Structure image for 5ors Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
2w1c Structure image for 2w1c Structure determination of Aurora Kinase in complex with inhibitor
3h0y Structure image for 3h0y Aurora A in complex with a bisanilinopyrimidine
3uo4 Structure image for 3uo4 Aurora A in complex with RPM1680
3uoj Structure image for 3uoj Aurora A in complex with RPM1715
4zts Structure image for 4zts Human Aurora A catalytic domain bound to FK1142
5os6 Structure image for 5os6 Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
2wqe Structure image for 2wqe Structure of S155R Aurora-A somatic mutant
3efw Structure image for 3efw Structure of AuroraA with pyridyl-pyrimidine urea inhibitor
3fdn Structure image for 3fdn Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity
3ha6 Structure image for 3ha6 Crystal structure of aurora A in complex with TPX2 and compound 10
3lau Structure image for 3lau Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor
4c3p Structure image for 4c3p Structure of dephosphorylated Aurora A (122-403) bound to TPX2 and AMPPCP
4ztr Structure image for 4ztr Human Aurora A catalytic domain bound to FK1141
5dn3 Structure image for 5dn3 Aurora A in complex with ATP and AA35.
5drd Structure image for 5drd Aurora A Kinase in Complex with ATP in Space Group P6122
5ort Structure image for 5ort Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
1ol6 Structure image for 1ol6 Structure of unphosphorylated D274N mutant of Aurora-A
3h10 Structure image for 3h10 Aurora A inhibitor complex
3uo6 Structure image for 3uo6 Aurora A in complex with YL5-083
5l8j Structure image for 5l8j Aurora-A kinase domain in complex with vNAR-D01 S93R
5l8k Structure image for 5l8k Aurora-A kinase domain in complex with vNAR-D01 (crystal form 2)
5orv Structure image for 5orv Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5orx Structure image for 5orx Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5os2 Structure image for 5os2 Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5osf Structure image for 5osf Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
2j50 Structure image for 2j50 Structure of Aurora-2 in complex with PHA-739358
3myg Structure image for 3myg Aurora A Kinase complexed with SCH 1473759
3w16 Structure image for 3w16 Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III
4jbo Structure image for 4jbo Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
5oro Structure image for 5oro Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5os5 Structure image for 5os5 Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
5osd Structure image for 5osd Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
6hjj Structure image for 6hjj Crystal structure of Aurora-A L210C catalytic domain in complex with ASDO6 ligand