Toll-like receptor 4 (O00206)

O00206 (TLR4_HUMAN)
Homo sapiens (Human)
839 amino acids (complete)
Source: UniProtKB

Protein family membership

Homologous superfamilies

  1. Homologous superfamily
1 100 200 300 400 500 600 700 839

Domains and repeats

1 100 200 300 400 500 600 700 839

Detailed signature matches

Unintegrated signatures no IPR
Unintegrated signatures

GO term prediction

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0007165 signal transduction
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042116 macrophage activation
GO:0045087 innate immune response
GO:0050707 regulation of cytokine secretion
GO:0050829 defense response to Gram-negative bacterium

Molecular Function

GO:0001875 lipopolysaccharide receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding

Cellular Component

GO:0016021 integral component of membrane
GO:0046696 lipopolysaccharide receptor complex