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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (E9Q4S1)

Accession
E9Q4S1 (PDE8B_MOUSE)
Species
Mus musculus (Mouse)
Length
865 amino acids (complete)
Source: UniProtKB

Protein family membership

Homologous superfamilies

  1. Homologous superfamily
1 100 200 300 400 500 600 700 800 865

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 865

Detailed signature matches

  1. Homologous superfamily IPR035965
    PAS domain superfamily
    1. SSF55785
  2. Homologous superfamily IPR036971
    3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
    1. G3DSA:1.10.13...
  3. Family IPR023088
    3'5'-cyclic nucleotide phosphodiesterase
    1. PR00387 (PDIESTERASE1)
  4. Domain IPR013938
    3'5'-cyclic nucleotide phosphodiesterase PDE8
    1. PF08629 (PDE8)
  5. Domain IPR000014
    PAS domain
    1. PF13426 (PAS_9)
    2. PS50112 (PAS)
    3. TIGR00229 (sensory_box)
    4. cd00130 (PAS)
    5. SM00091 (PAS)
  6. Domain IPR003607
    HD/PDEase domain
    1. SM00471 (HDc)
    2. cd00077 (HDc)
  7. Domain IPR002073
    3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    1. PF00233 (PDEase_I)
    2. PS51845 (PDEASE_I_2)
  8. SITE IPR023174
    3'5'-cyclic nucleotide phosphodiesterase, conserved site
    1. PS00126 (PDEASE_I_1)

Other features

  1. mobidb-lite (disord...)
  2. mobidb-lite (Polyam...)
  3. mobidb-lite (Polar)

Residue annotation

  1. putative active si...
  2. heme pocket cd00130
  3. Zn2+ binding site ...
  4. Mg2+ binding site ...

GO term prediction

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity

Cellular Component

None predicted.