E3 ubiquitin-protein ligase HECTD3 (IPR042469)

Short name: HECTD3

Overlapping homologous superfamilies


Family relationships



E3 ubiquitin-protein ligase HECTD3 is an E3 ubiquitin ligase that regulates ubiquitination and degradation of Tara [PMID: 18194665], MASTL and LKB1 [PMID: 28636940]. HECTD3 interacts with HSP90 and is involved in the HSP90-dependent degradation of CRAF protein [PMID: 28636940]. It has been shown to interact and stabilize MALT1 (mucosa-associated lymphoid tissue 1), and may hence promote cell survival [PMID: 23358872].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.