CD70 antigen (IPR042374)

Short name: CD70

Overlapping homologous superfamilies

Family relationships



CD70 is a ligand of CD27 and is a TNF related transmembrane protein induced upon activation on T and B cells [PMID: 30635649]. The CD27/CD70 interaction plays a key role in T dependent B cell responses and is responsible for plasma cell differentiation [PMID: 10803880]. The CD27/CD70 pathway has been shown to contribute to the pathophysiology of autoimmunity [PMID: 26359318].

GO terms

Biological Process

GO:0033209 tumor necrosis factor-mediated signaling pathway

Molecular Function

GO:0005164 tumor necrosis factor receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.