Homologous Superfamily

AMP-dependent synthetase-like superfamily (IPR042099)

Short name: AMP-dep_Synthh-like_sf

Overlapping entries


This region is a Ser/Thr/Gly-rich domain that is further characterised by a conserved Pro-Lys-Gly triplet. The superfamily of enzymes includes luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely-related synthetases [PMID: 26473393].

Acetyl-coenzyme A synthetase catalyzes the two-step synthesis of acetyl-CoA from acetate, ATP, and CoA and belongs to a family of adenylate-forming enzymes that generate an acyl-AMP intermediate. The three-dimensional structure of Acetyl-coenzyme A synthetase is composed of two domains. The large N-terminal domain is formed by two mostly parallel eight-stranded beta-sheets. The C-terminal domain begins with a short loop containing two antiparallel strands followed by a three-stranded beta-sheet that is surrounded on both sides by two alpha-helices [PMID: 12627952].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.